Development of hybrid scaffold: Bioactive glass nanoparticles/chitosan for tissue engineering applications

Autor: Jihen Refifi, Nicolas Rocton, Siwar Mosbahi, Bertrand Lefeuvre, Sanaa Najem, Hafedh El Feki, Hassane Oudadesse
Přispěvatelé: Institut des Sciences Chimiques de Rennes (ISCR), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA), Université de Sfax - University of Sfax, CNRS, Centre National de la Recherche Scientifique, Université de Rennes 1, Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)
Rok vydání: 2020
Předmět:
Scaffold
Materials science
Polymers
0206 medical engineering
Composite number
Biomedical Engineering
Nanoparticle
Biocompatible Materials
02 engineering and technology
scaffold
hybrid biomaterial
law.invention
Biomaterials
Chitosan
chemistry.chemical_compound
X-Ray Diffraction
Tissue engineering
law
Absorbable Implants
Freezing
Materials Testing
Spectroscopy
Fourier Transform Infrared
[CHIM]Chemical Sciences
Bone regeneration
Nano Bioactive glass
Acetic Acid
Tissue Engineering
Tissue Scaffolds
Metals and Alloys
Hydrogen-Ion Concentration
021001 nanoscience & nanotechnology
020601 biomedical engineering
Biodegradable polymer
Solutions
chemistry
Chemical engineering
Bioactive glass
Microscopy
Electron
Scanning
Ceramics and Composites
Nanoparticles
[SDV.IB]Life Sciences [q-bio]/Bioengineering
Glass
0210 nano-technology
Gels
Porosity
chemical reactivity
Zdroj: Journal of Biomedical Materials Research Part A
Journal of Biomedical Materials Research Part A, Wiley, 2021, 109 (5), pp.590-599. ⟨10.1002/jbm.a.37043⟩
Journal of Biomedical Materials Research Part A, 2021, 109 (5), pp.590-599. ⟨10.1002/jbm.a.37043⟩
ISSN: 1552-4965
1549-3296
DOI: 10.1002/jbm.a.37043
Popis: International audience; Bone tissue engineering is gaining popularity as an alternative method for the treatment of osseous defects. A number of biodegradable polymers have been explored for tissue engineering purposes. A new family of biodegradable polymer/bioactive glass composite materials has been designed to be used in bone regeneration approaches. In this work, a hybrid scaffold of chitosan (CH) and bioactive glass nanoparticles (BGN) was prepared by the freeze-gelation method. This method has been studied by adjusting the concentration of acetic acid; this process can influence the structure properties of the scaffold. In this work, several BGN/CH composites have been prepared by varying the proportion of BGN in the hybrid scaffold (20, 40, 60, and 80%). Brunauer-Emmett-Teller results showed the increased surface area and porosity volume of our composite with decreasing BGN proportion. BGN/CH hybrid scaffold was characterized by using physicochemical techniques. Obtained results showed a macroporous morphology of the scaffold with a pore size of about 200 μm, and a homogeneous distribution of the BGN in the CH matrix. X-ray diffraction study confirmed the amorphous state of the BGN/CH hybrid scaffold. Interaction between CH and BGNs in the composite was confirmed. The in vitro assays showed adequate degradation properties, which is essential for the potential replacement by the new tissue. The in vitro bioactivity studies confirmed the formation of an apatite layer on the surface of the hybrid scaffold, which results in a direct bone bonding of the implant. These results indicate that BGN/CH hybrid scaffold developed is a potential candidate for bone tissue engineering.
Databáze: OpenAIRE
Externí odkaz: