Measurement of corticosterone in mice: a protocol for a mapping review
| Autor: | Leenaars, Cathalijn H C, van der Mierden, Stevie, Durst, Mattea, Goerlich-Jansson, Vivian C, Ripoli, Florenza Lüder, Keubler, Lydia M, Talbot, Steven R, Boyle, Erin, Habedank, Anne, Jirkof, Paulin, Lewejohann, Lars, Gass, Peter, Tolba, René, Bleich, André, Sustainable Animal Stewardship, dASS BW-2, Animal Behaviour |
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| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
specimen detection Specimen Handling mapping review 03 medical and health sciences chemistry.chemical_compound Severity assessment Mice 0302 clinical medicine systematic review Corticosterone medicine Animals Intensive care medicine Animal species Saliva 030304 developmental biology Protocol (science) 0303 health sciences General Veterinary business.industry Stressor Milk Data extraction chemistry Animal Science and Zoology Systematic mapping business 030217 neurology & neurosurgery Systematic Reviews as Topic |
| Zdroj: | Laboratory Animals. SAGE |
| ISSN: | 1758-1117 0023-6772 |
| Popis: | Severity assessment for experiments conducted with laboratory animals is still based mainly on subjective evaluations; evidence-based methods are scarce. Objective measures, amongst which determination of the concentrations of stress hormones, can be used to aid severity assessment. Short-term increases in glucocorticoid concentrations generally reflect healthy responses to stressors, but prolonged increases may indicate impaired welfare. As mice are the most commonly used laboratory animal species, we performed a systematic mapping review of corticosterone measurements in Mus musculus, to provide a full overview of specimen types (e.g. blood, urine, hair, saliva, and milk) and analysis techniques. In this publication, we share our protocol and search strategy, and our rationale for performing this systematic analysis to advance severity assessment. So far, we have screened 13,520 references, and included 5337 on primary studies with measurements of endogenous corticosterone in M. musculus. Data extraction is currently in progress. When finished, this mapping review will be a valuable resource for scientists interested in corticosterone measurements to aid severity assessment. We plan to present the data in a publication and a searchable database, which will allow for even easier retrieval of the relevant literature. These resources will aid implementation of objective measures into severity assessment. |
| Databáze: | OpenAIRE |
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