The Regulation of Collagen Processing by miRNAs in Disease and Possible Implications for Bone Turnover
| Autor: | Tomasz P. Lehmann, Urszula Guderska, Klaudia Kałek, Maria Marzec, Agnieszka Urbanek, Alicja Czernikiewicz, Maria Sąsiadek, Paweł Karpiński, Andrzej Pławski, Maciej Głowacki, Paweł P. Jagodziński |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
bone turnover
QH301-705.5 extracellular matrix collagen type I Review Catalysis Bone and Bones Inorganic Chemistry Calcification Physiologic Osteogenesis Animals Humans Physical and Theoretical Chemistry Biology (General) Molecular Biology QD1-999 Spectroscopy miRNA Organic Chemistry non-collagenous proteins General Medicine Computer Science Applications Chemistry MicroRNAs Bone Remodeling Collagen |
| Zdroj: | International Journal of Molecular Sciences International Journal of Molecular Sciences, Vol 23, Iss 91, p 91 (2022) |
| ISSN: | 1422-0067 |
| Popis: | This article describes several recent examples of miRNA governing the regulation of the gene expression involved in bone matrix construction. We present the impact of miRNA on the subsequent steps in the formation of collagen type I. Collagen type I is a main factor of mechanical bone stiffness because it constitutes 90–95% of the organic components of the bone. Therefore, the precise epigenetic regulation of collagen formation may have a significant influence on bone structure. We also describe miRNA involvement in the expression of genes, the protein products of which participate in collagen maturation in various tissues and cancer cells. We show how non-collagenous proteins in the extracellular matrix are epigenetically regulated by miRNA in bone and other tissues. We also delineate collagen mineralisation in bones by factors that depend on miRNA molecules. This review reveals the tissue variability of miRNA regulation at different levels of collagen maturation and mineralisation. The functionality of collagen mRNA regulation by miRNA, as proven in other tissues, has not yet been shown in osteoblasts. Several collagen-regulating miRNAs are co-expressed with collagen in bone. We suggest that collagen mRNA regulation by miRNA could also be potentially important in bone metabolism. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|