The Relation of Plasmacytoid Dendritic Cells (pDCs) and Regulatory T-Cells (Tregs) with HPV Persistence in HIV-Infected and HIV-Uninfected Women
| Autor: | Xiaonan Xue, L. Stewart Massad, Kathryn Anastos, Howard Minkoff, Alan L. Landay, Xianhong Xie, Jeffrey Martinson, Seema Desai, Gypsyamber D'Souza, Howard D. Strickler, Robert D. Burk, Alexandra M. Levine, D. Heather Watts, Joel M. Palefsky, Christine Colie |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
CD4-Positive T-Lymphocytes
Adult T-Lymphocytes Immunology Human immunodeficiency virus (HIV) Uterine Cervical Neoplasms HIV Infections Pilot Projects Biology Cervical Cancer medicine.disease_cause T-Lymphocytes Regulatory Hpv persistence Immune system Antigen Downregulation and upregulation Acquired immunodeficiency syndrome (AIDS) Clinical Research Virology medicine Humans 2.1 Biological and endogenous factors Aetiology Cancer Cervical cancer Effector Brief Report Prevention Papillomavirus Infections virus diseases hemic and immune systems Dendritic Cells medicine.disease Regulatory CD4 Lymphocyte Count Infectious Diseases Chronic Disease Sexually Transmitted Infections HIV/AIDS Molecular Medicine Female Infection |
| Zdroj: | Viral immunology, vol 27, iss 1 |
| ISSN: | 1557-8976 0882-8245 |
| DOI: | 10.1089/vim.2013.0097 |
| Popis: | Other than CD4+ count, the immunologic factors that underlie the relationship of HIV/AIDS with persistent oncogenic HPV (oncHPV) and cervical cancer are not well understood. Plasmacytoid dendritic cells (pDCs) and regulatory T-cells (Tregs) are of particular interest. pDCs have both effector and antigen presenting activity and, in HIV-positive patients, low pDC levels are associated with opportunistic infections. Tregs downregulate immune responses, and are present at high levels in HIV-positives. The current pilot study shows for the first time that low pDC and high Treg levels may be significantly associated with oncHPV persistence in both HIV-positive and HIV-negative women. Larger studies are now warranted. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|