Apolipoprotein B: novel indicator of elevated intraocular pressure
| Autor: | Y K Chung, Jun-Seok Son, J H Son |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty genetic structures Apolipoprotein B Blood Pressure Systemic health Body Mass Index Coronary artery disease Tonometry Ocular Young Adult Elevated intraocular pressure chemistry.chemical_compound Nephelometry and Turbidimetry Internal medicine Humans Medicine Intraocular Pressure Triglycerides Aged Anthropometry biology Triglyceride business.industry Cholesterol HDL Cholesterol LDL Middle Aged medicine.disease Ophthalmology Cholesterol Endocrinology Blood pressure chemistry Apolipoprotein B-100 Clinical Study biology.protein Female Ocular Hypertension lipids (amino acids peptides and proteins) Apolipoprotein A1 business Body mass index |
| Zdroj: | Eye. 29:1315-1320 |
| ISSN: | 1476-5454 0950-222X |
| DOI: | 10.1038/eye.2015.37 |
| Popis: | Many studies have reported associations between elevated intraocular pressure (IOP) and systemic health parameters, which suggest a common mechanism links IOP elevation and various related cardiometabolic risk factors. Furthermore, according to a recent study, serum apolipoprotein B (APO B) level is a predictor of coronary artery disease. This study was undertaken to analyse the relationship between serum apolipoprotein levels and IOP. Healthy people (28 852) who attended a community hospital for a health checkup between January 2011 and December 2013 were enroled in the study. We measured age, body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), serum levels of total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and apolipoprotein A1 (APO A1) and APO B, APO B/APO A1 ratios, and IOP. Univariate regression analysis showed IOP was positively correlated with BMI, SBP, DBP, TC, LDL-C, TG, APO B, and APO B/APO A1 (P |
| Databáze: | OpenAIRE |
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