PRRSV structure, replication and recombination: Origin of phenotype and genotype diversity
| Autor: | Matthew A. Kappes, Kay S. Faaberg |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Arterivirus
Genotype animal diseases viruses Replication Subgenomic RNA Heteroclite Virus Replication Article Virus Virology Animals Porcine respiratory and reproductive syndrome virus Pathogen Subgenomic mRNA Recombination Genetic Genetics biology Virion Genetic Variation respiratory system biology.organism_classification Porcine reproductive and respiratory syndrome virus Phenotype Recombination Vaccination |
| Zdroj: | Virology |
| ISSN: | 0042-6822 |
| DOI: | 10.1016/j.virol.2015.02.012 |
| Popis: | Porcine reproductive and respiratory disease virus (PRRSV) has the intrinsic ability to adapt and evolve. After 25 years of study, this persistent pathogen has continued to frustrate efforts to eliminate infection of herds through vaccination or other elimination strategies. The purpose of this review is to summarize the research on the virion structure, replication and recombination properties of PRRSV that have led to the extraordinary phenotype and genotype diversity that exists worldwide. Highlights • Review of structure, replication and recombination of porcine reproductive and respiratory syndrome virus. • Homologous recombination to produce conventional subgenomic messenger RNA as well as heteroclite RNA. • Discussion of structure, replication and recombination mechanisms that have yielded genotypic and phenotypic diversity. |
| Databáze: | OpenAIRE |
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