The Effect of Low-Dose Remifentanil on Responses to the Endotracheal Tube During Emergence from General Anesthesia
| Autor: | Achir A. Al-Alami, Marie T. Aouad, Reine A. Zbeidy, Sahar M. Siddik-Sayyid, Fouad G. Souki, Viviane G. Nasr |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors Adolescent Psychomotor agitation medicine.drug_class medicine.medical_treatment Remifentanil Hemodynamics Blood Pressure Anesthesia General Nose Severity of Illness Index Drug Administration Schedule Young Adult Double-Blind Method Piperidines Heart Rate Tachycardia Heart rate Intubation Intratracheal medicine Humans Intubation Prospective Studies Infusions Intravenous Psychomotor Agitation business.industry Middle Aged Surgery Analgesics Opioid Treatment Outcome Anesthesiology and Pain Medicine Blood pressure Cough Sedative Anesthesia Anesthesia Recovery Period Female Hypotension medicine.symptom business medicine.drug |
| Zdroj: | Anesthesia & Analgesia. 108:1157-1160 |
| ISSN: | 0003-2999 |
| DOI: | 10.1213/ane.0b013e31819b03d8 |
| Popis: | Background Emergence from general anesthesia can be associated with coughing, agitation, and hemodynamic disturbances. Remifentanil may attenuate these responses. Methods In a prospective, double-blind, randomized trial, we enrolled 60 adult patients undergoing nasal surgery using remifentanil-based anesthesia. During the emergence phase, the remifentanil group had remifentanil reduced to one tenth of the maintenance rate, whereas the control group had remifentanil discontinued. Results Times to awakening and tracheal extubation were similar between the two groups. During emergence, the remifentanil group (infusion rate 0.014 +/- 0.011 microg x kg(-1) x min(-1)) had a significantly lower incidence (40% vs 80%, P = 0.002) and less severe coughing compared with the control group, as well as a lower incidence of nonpurposeful movement (3.3% vs 30%, P = 0.006) and slower heart rates. Conclusions Low-dose remifentanil during emergence did not prolong wake-up but reduced the incidence and severity of coughing from the endotracheal tube. |
| Databáze: | OpenAIRE |
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