Validation of the diagnostic criteria of the consensus definition of fracture-related infection

Autor: Jolien Onsea, Esther M.M. Van Lieshout, Charalampos Zalavras, Jonathan Sliepen, Melissa Depypere, Nathalie Noppe, Jamie Ferguson, Michael H.J. Verhofstad, Geertje A.M. Govaert, Frank F.A. IJpma, Martin A. McNally, Willem-Jan Metsemakers
Přispěvatelé: ​Basic and Translational Research and Imaging Methodology Development in Groningen (BRIDGE), Surgery
Rok vydání: 2021
Předmět:
Zdroj: Injury, 53(6), 1867-1879. ELSEVIER SCI LTD
Injury, 53(6), 1867-1879. Elsevier Ltd.
ISSN: 1879-0267
0020-1383
Popis: BACKGROUND: The recently developed fracture-related infection (FRI) consensus definition, which is based on specific diagnostic criteria, has not been fully validated in clinical studies. We aimed to determine the diagnostic performance of the criteria of the FRI consensus definition and evaluated the effect of the combination of certain suggestive and confirmatory criteria on the diagnostic performance. METHODS: A multicenter, multi-national, retrospective cohort study was performed. Patients were subdivided into an FRI or a control group, according to the treatment they received and the recommendations from a multidisciplinary team ('intention to treat'). Exclusion criteria were patients with an FRI diagnosed outside the study period, patients younger than 18 years of age, patients with pathological fractures or patients with fractures of the skull, cervical, thoracic and lumbar spine. Minimum follow up for all patients was 18 months. RESULTS: Overall, 637 patients underwent revision surgery for suspicion of FRI. Of these, 480 patients were diagnosed with FRI, treated accordingly, and included in the FRI group. The other 157 patients were included in the control group. The presence of at least one confirmatory sign was associated with a sensitivity of 97.5%, a specificity of 100% and a high discriminatory value (AUROC 0.99, p
Databáze: OpenAIRE
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