The Synthesis of Phosphaisocoumarins by Cu(I)-Catalyzed Intramolecular Cyclization of o-Ethynylphenylphosphonic Acid Monoesters
| Autor: | Yi-Xiang Ding, Ai-Yun Peng |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Reaction mechanism
Intramolecular reaction Organophosphonates chemistry.chemical_element Crystallography X-Ray Biochemistry Medicinal chemistry Catalysis Colloid and Surface Chemistry Coumarins Catalyst selectivity Organic chemistry Enzyme Inhibitors Protein Tyrosine Phosphatase Non-Receptor Type 1 Molecular Structure Chemistry Phosphorus Intramolecular cyclization Regioselectivity General Medicine General Chemistry Iodides Cyclization Alkynes Intramolecular force Protein Tyrosine Phosphatases Copper |
| Zdroj: | Journal of the American Chemical Society. 125:15006-15007 |
| ISSN: | 1520-5126 0002-7863 |
| Popis: | Cu(I)-catalyzed intramolecular cyclization of o-ethynylphenylphosphonic acid monoethyl esters was examined, and a new class of six-membered phosphorus heterocycles was formed with high regioselectivity and good yields. The present reaction is the first example of intramolecular addition of P-OH to alkynes, which provides a convenient way to synthesize novel phosphorus heterocycles having potential bioactivities. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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