THE EFFECT OF 5-BROMODEOXYURIDINE ON THE RECOVERY PHENOMENON IN SUB-LETHALLY IRRADIATED CELLS
| Autor: | M.L. Eidinoff, J.H. Kim, N. Delihas, J.S. Laughlin |
|---|---|
| Rok vydání: | 1964 |
| Předmět: |
Pharmacology
Research Lethal dose Uracil Nucleosides Cell Biology DNA Biology biology.organism_classification Molecular biology Thymine HeLa Tissue Culture Techniques chemistry.chemical_compound Tissue culture Radiation Injuries Experimental chemistry Bromodeoxyuridine Nucleic acid Radiation Injuries |
| Zdroj: | Experimental cell research. 36 |
| ISSN: | 0014-4827 |
| Popis: | Recovery phenomena in sub-lethally irradiated mammalian cells in culture were studied after treatment with 5-bromodeoxyuridine to examine whether the general shape of the recovery curve could be altered when DNA thymine was partially replaced by 5-bromouracil. The extent of replacement of thymine in the H.Ep. No. 1 and HeLa S-3 cells by 5-bromouracil was about one and twelve per cent respectively. The recovery was evident even after treatment with 5-bromodeoxyuridine and the pattern of the recovery curve was not appreciably altered in both the H.Ep. No. 1 and HeLa S-3 cells. |
| Databáze: | OpenAIRE |
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