Hemodynamic effects of calcium antagonists with high or low vascular selectivity
| Autor: | May Sjölander, Peter Thorén, Margareta Nordlander |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Male
medicine.medical_specialty Cardiac output chemistry.chemical_element Blood Pressure Calcium Muscle Smooth Vascular medicine.artery Internal medicine Rats Inbred SHR Ascending aorta medicine Animals Cardiac Output Hemodynamic effects Pharmacology Felodipine Hemodynamics Heart Calcium Channel Blockers Myocardial Contraction Rats Blood pressure Vascular selectivity chemistry Verapamil cardiovascular system Cardiology Vascular Resistance Cardiology and Cardiovascular Medicine medicine.drug |
| Zdroj: | Journal of cardiovascular pharmacology. 15 |
| ISSN: | 0160-2446 |
| Popis: | Summary: Infusion of felodipine and verapamil in increasing doses to anesthetized spontaneously hypertensive rats induced a progressive fall in arterial blood pressure (BP). To estimate the cardiac action of the different drugs, we also measured changes in cardiac output (CO) and velocity of flow (dF/dT) by a Doppler flow probe placed on the ascending aorta. Infusion of verapamil induced a parallel decrease in mean arterial BP, CO, and cardiac inotropy (as estimated by max. dF/dT). In contrast, upon felodipine administration, the decrease in arterial BP was accompanied by an initial small rise in dF/dT. A decrease in dF/dT was observed only after high doses of felodipine, which cause pronounced levels of hypotension. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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