Parkinson’s-adapted cognitive stimulation therapy: a pilot randomized controlled clinical trial
| Autor: | Joanne Rodda, Orgeta, C Taylor, Lesley-Anne Carter, Sheree A McCormick, Monty Silverdale, J Raw, Sabina Vatter, Iracema Leroi, Sarah J. Smith, Ellen Poliakoff, T Abdel-Ghany, David J. Ahearn |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
ResearchInstitutes_Networks_Beacons/MICRA psychosocial therapy Cost effectiveness Population lcsh:RC346-429 law.invention 03 medical and health sciences 0302 clinical medicine Quality of life (healthcare) Randomized controlled trial law Parkinson’s disease dementia (PDD) mental disorders Medicine Dementia 030212 general & internal medicine education lcsh:Neurology. Diseases of the nervous system Original Research feasibility pilot trial Pharmacology education.field_of_study dementia with Lewy bodies (DLB) business.industry Dementia with Lewy bodies Cognition medicine.disease Clinical trial cognitive stimulation therapy (CST) Manchester Institute for Collaborative Research on Ageing Neurology Physical therapy Neurology (clinical) business human activities 030217 neurology & neurosurgery |
| Zdroj: | Therapeutic Advances in Neurological Disorders, Vol 12 (2019) Leroi, I, Vatter, S, Carter, L-A, Smith, S J, Ortega, V, Poliakoff, E, Silverdale, M, Raw, J, Ahearn, D J, Taylor, C, Rodda, J, Abdel-Ghany, T & Mccormick, S 2019, ' Parkinson’s-adapted Cognitive Stimulation Therapy: A pilot randomised controlled clinical trial ', Therapeutic Advances in Neurological Disorders . https://doi.org/10.1177/1756286419852217 Therapeutic Advances in Neurological Disorders |
| ISSN: | 1756-2856 |
| Popis: | Cognitive stimulation therapy (CST) is widely used with people with dementia, but there is no evidence of its efficacy in mild cognitive impairment or dementia in Parkinson’s disease (PD-MCI; PDD) or dementia with Lewy bodies (DLB). We aimed to explore the impact of ‘CST-PD’, which is home-based, individualized CST adapted for this population. In a single-blind, randomized controlled exploratory pilot trial (RCT), we randomized 76 participant–dyads [PD-MCI ( n = 15), PDD ( n = 40), DLB ( n = 21) and their care partners] to CST-PD or treatment as usual (TAU). CST-PD involves home-based cognitively stimulating and engaging activities delivered by a trained care partner. Exploratory outcomes at 12 weeks included cognition (Addenbrooke’s Cognitive Evaluation; ACE-III), neuropsychiatric symptoms and function. In care partners, we assessed burden, stress and general health status. Relationship quality and quality of life were assessed in both dyad members. At 12 weeks, the ACE-III showed a nonstatistically significant improvement in the CST-PD group compared with the TAU group, although neuropsychiatric symptoms increased significantly in the former. In contrast, care partners’ quality of life ( d = 0.16) and relationship quality (‘satisfaction’, d = 0.01; ‘positive interaction’, d = 0.55) improved significantly in the CST-PD group, and care burden ( d = 0.16) and stress ( d = 0.05) were significantly lower. Qualitative findings in the CST-PD recipients revealed positive ‘in the moment’ responses to the intervention, supporting the quantitative results. In conclusion, care-partner-delivered CST-PD may improve a range of care-partner outcomes that are important in supporting home-based care. A full-scale follow-up RCT to evaluate clinical and cost effectiveness is warranted. |
| Databáze: | OpenAIRE |
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