'Low-Fat' Pseudoangiomatous Spindle Cell Lipoma
| Autor: | John C. Maize, Jonathan S. Ralston, Jessica A. Forcucci, Jessica Zarah Sugianto, Daynna J. Wolff |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Pathology medicine.medical_specialty Extraordinary Case Report Dermatology Biology Pathology and Forensic Medicine Diagnosis Differential Hemangioma Biomarkers Tumor otorhinolaryngologic diseases medicine Humans fluorescence in situ hybridization In Situ Hybridization Fluorescence Aged pseudoangiomatous Chromosomes Human Pair 13 medicine.diagnostic_test General Medicine Anatomy Lipoma medicine.disease Immunohistochemistry 13q14 Spindle cell lipoma spindle cell lipoma Pleomorphic lipoma Differential diagnosis Neck Myofibroblastoma Fluorescence in situ hybridization |
| Zdroj: | The American Journal of Dermatopathology |
| ISSN: | 0193-1091 |
| DOI: | 10.1097/dad.0000000000000286 |
| Popis: | Spindle cell and pleomorphic lipoma constitute a spectrum of lipomatous lesions with characteristic clinical, morphologic, immunohistochemical, and molecular features. Multiple variants have been previously described including vascular, fibrous, plexiform, and those with significantly less fat termed “low-fat” and “fat-free” by Folpe. Cytogenetically, spindle cell lipomas frequently display monoallelic loss of 13q14 region, an abnormality also found in cellular angiofibroma and mammary-type myofibroblastoma. Pseudoangiomatous spindle cell lipoma, originally described by Fletcher et al in 1994, is a rare variant within the spindle cell/pleomorphic lipoma spectrum, with less than 20 published cases. It consists of an admixture of spindle cells, “ropey” collagen, variable amounts of mature fat, and irregular, branching slit-like vascular spaces. The authors present a case of a 1-cm subcutaneous lesion excised from the neck of a 70-year-old man with classic histologic and immunohistochemical features of “low-fat” pseudoangiomatous spindle cell lipoma. Fluorescence in situ hybridization demonstrated a loss of 13q14 region, a characteristic presumed cytogenetic finding of spindle cell lipoma, which has been previously unconfirmed in this variant. |
| Databáze: | OpenAIRE |
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