L-amphetamine improves memory in MS patients with objective memory impairment
| Autor: | Tanya Kaushik, Nancy D. Chiaravalloti, John DeLuca, James F. Sumowski, Ralph H.B. Benedict, David Erlanger |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male Memory Disorders medicine.medical_specialty Multiple Sclerosis Multiple sclerosis L-Amphetamine Neuropsychology Middle Aged Neuropsychological Tests medicine.disease Clinical trial Amphetamine Treatment Outcome Double-Blind Method Neurology Memory medicine Humans Memory impairment Female Neurology (clinical) Psychiatry Psychology |
| Zdroj: | Multiple Sclerosis Journal. 17:1141-1145 |
| ISSN: | 1477-0970 1352-4585 |
| DOI: | 10.1177/1352458511404585 |
| Popis: | Background: Memory impairment is prevalent in multiple sclerosis (MS), but no drugs are approved to treat these memory problems. Objective: The objective of the study was to examine the effect of l-amphetamine versus placebo on auditory/verbal memory and visual/spatial memory in MS patients with and without baseline memory impairment. Methods: We conducted a re-analysis of a previously published clinical trial in which MS patients were randomly assigned to treatment (30 mg l-amphetamine, N = 99) or placebo ( N = 37) in a four-week, double-blind, parallel-group, dose titration trial. Auditory/verbal memory (CVLT-II: Long Delay Free Recall) and visual/spatial memory (BVMT-R: Delayed Recall) were assessed at baseline and follow-up across subgroups of patients with intact baseline memory (mean = 50th percentile) or impaired baseline memory (mean = 2nd percentile). Primary analyses: 2 ( l-amphetamine, placebo) × 2 (baseline, follow-up), × 2 (baseline memory intact, baseline memory impaired) ANOVAs performed separately for auditory/verbal and visual/spatial memory. Results: For both auditory/verbal and visual/spatial memory, we observed significant 2 × 2 × 2 interactions whereby l-amphetamine improved memory more than placebo, and this effect was specific to patients with baseline memory impairment. Conclusions: Among memory-impaired patients, memory improved about 48.5% for those on l-amphetamine, but only 1.0% on placebo. Treatment with l-amphetamine produced large memory gains among memory-impaired MS patients. |
| Databáze: | OpenAIRE |
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