Ethanol-induced signal transducing mechanism associated with a transient antiviral state in human amniotic cells
| Autor: | I. Földes, G. Premecz, T Farkas, J Nagy, I Lörincz, G. Bagi, A. Markovits |
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| Rok vydání: | 1994 |
| Předmět: |
Cell signaling
Medicine (miscellaneous) Phosphatidylinositols Virus Replication Vesicular stomatitis Indiana virus Cell Line medicine Humans Amnion Protein kinase A General Psychology Protein kinase C Protein Kinase C Phospholipase C biology Dose-Response Relationship Drug Ethanol Chemistry Hydrolysis Interferon-beta biology.organism_classification Virology Cell biology Enzyme Activation medicine.anatomical_structure Cell culture Vesicular stomatitis virus Type C Phospholipases Calcium Signal transduction Signal Transduction |
| Zdroj: | Journal of studies on alcohol. 55(4) |
| ISSN: | 0096-882X |
| Popis: | Short-term effects of ethanol on human amnion cells were investigated by studying the cellular signaling processes and the replication of vesicular stomatitis virus. Treatment of human amniotic cells with ethanol transiently triggers the breakdown of inositol phospholipids, stimulates intracellular [Ca2+]i mobilization and activates the translocation of protein kinase C. Activation of this signal transduction mechanism is associated with the development of an antiviral state, as proven by studying 3H-uridine incorporation into the RNA of vesicular stomatitis virus. Induction of the antiviral state in human amniotic cells correlates with the solubility of the alcohols in the lipid membrane of the cells. |
| Databáze: | OpenAIRE |
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