Six novel steroids from culture of basidiomycete Polyporus ellisii
| Autor: | Ling Zhang, Ze-Jun Dong, Zheng-Hui Li, Ji-Kai Liu, Liang-Yan Liu, Shuang Wang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Stereochemistry
Tumor cells Plant Science Toxicology Bioinformatics Biochemistry Analytical Chemistry chemistry.chemical_compound Cytotoxicity Spectral data Pharmacology Ergosterol biology ergosterol Organic Chemistry Regular Article biology.organism_classification Polyporus chemistry Cell culture cytotoxicity Polyporus ellisii Two-dimensional nuclear magnetic resonance spectroscopy Human cancer Food Science basidiomycete |
| Zdroj: | Natural Products and Bioprospecting |
| ISSN: | 2192-2209 2192-2195 |
| Popis: | Investigation of the culture of basidiomycete Polyporus ellisii led to the isolation of a novel compound 3β,9α,15α-trihydroxy-(22E,24R)-10(5→4)-abeo-ergosta-6,8(14),22-trien-5-one (1) with a new 5/7/6/5 ring system of ergosterol skeleton. In addition, five new steroids, 5β,6β-epoxy-3β,7α,9α-trihydroxy-(22E,24R)-ergosta-8(14),22-dien-15-one (2), 5β,6β-epoxy-3β,7α-dihydroxy-(22E,24R)-ergosta-8(14),22-dien-15-one (3), 5α,6α-epoxy-3β,9α,15α-trihydroxy-(22E,24R)-ergosta-8(14),22-dien-7-one (4), 15α-acetoxy-(22E,24R)-ergosta-4,6,8(14),22-tetraen-3-one (5), 15β-methoxy-(22E,24R)-ergosta-4,6,8(14),22-tetraen-3-one (6), along with four known ergosterols (7–10), were obtained. All structures were elucidated based on 1D and 2D NMR spectral data. New compounds were evaluated for cytotoxicity against five human cancer cell lines, only compound 4 was found to exhibit a favorable cytotoxicity profile toward all tested tumor cell lines. |
| Databáze: | OpenAIRE |
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