Carbon monoxide: a novel pulmonary artery vasodilator in neonatal llamas of the Andean altiplano
| Autor: | Renato Ebensperger, Paola Casanello, Emilia M. Sanhueza, Emilio A. Herrera, Esteban Sepúlveda-Kattan, Natalia Mendez, Roberto V. Reyes, Julian T. Parer, Dino A. Giussani, Carlos E. Blanco, Germán Ebensperger, Mark A. Hanson, Aníbal J. Llanos, Raquel A. Riquelme, Victor M Pulgar, Gertrudis Cabello |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
medicine.medical_specialty
Physiology Blood Pressure Pulmonary Artery Nitric Oxide Nitric oxide chemistry.chemical_compound Physiology (medical) Internal medicine medicine.artery Hypoxic pulmonary vasoconstriction biology.domesticated_animal Animals Medicine Carbon Monoxide Sheep Lung biology business.industry Altitude Effects of high altitude on humans medicine.disease Pulmonary hypertension Lama glama Oxygen Vasodilation Endocrinology medicine.anatomical_structure Animals Newborn chemistry Anesthesia Pulmonary artery Cardiology and Cardiovascular Medicine business Soluble guanylyl cyclase Camelids New World Heme Oxygenase-1 |
| Zdroj: | CARDIOVASCULAR RESEARCH Artículos CONICYT CONICYT Chile instacron:CONICYT |
| ISSN: | 0008-6363 |
| DOI: | 10.1093/cvr/cvm013 |
| Popis: | Aims To study the nitric oxide (NO) and carbon monoxide roles in the regulation of the pulmonary circulation in lowland and highland newborn sheep and llamas. Methods and results We used neonatal sheep (Ovis aries) and llamas (Lama glama) whose gestation and delivery took place at low (580 m) or high (3600 m) altitude. In vivo, we measured the cardiopulmonary function basally and with a NO synthase (NOS) blockade and calculated the production of carbon monoxide by the lung. In vitro, we determined NOS and soluble guanylate cyclase (sGC) expression, NOS activity, and haemoxygenase (HO) expression in the lung. Pulmonary arterial pressure was elevated at high altitude in sheep but not in llamas. Sheep at high altitude relative to sea level had significantly greater total lung NOS activity and eNOS protein, but reduced sGC and HO expression and carbon monoxide production. In contrast, llamas showed no difference in NO function between altitudes, but a pronounced increase in pulmonary carbon monoxide production and HO expression at high altitude. Conclusions In the llama, enhanced pulmonary carbon monoxide, rather than NO, protects against pulmonary hypertension in the newborn period at high altitude. This shift in pulmonary dilator strategy from NO to carbon monoxide has not been previously described, and it may give insight into new treatments for excessive pulmonary vasoconstriction. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|