Autologous bone marrow-derived stem cell therapy in combination with TMLR. A novel therapeutic option for endstage coronary heart disease: report on 2 cases
| Autor: | N. Feifel, Emmeran Gams, Ludger Wilhelm Poll, J. Draganov, HM Klein, E. R. Burchardt, Volker R. Stoldt, A. Saleh, C. Piecharczek, M Stockschläder, A Ghodsizad, Andreas Borowski |
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| Rok vydání: | 2005 |
| Předmět: |
medicine.medical_specialty
Angiogenesis medicine.medical_treatment Coronary Disease Revascularization Transplantation Autologous Cell therapy Contractility Internal medicine Myocardial Revascularization Medicine Combined Modality Therapy Humans Aged Bone Marrow Transplantation business.industry Hematopoietic Stem Cell Transplantation Coronary heart disease Transplantation Treatment Outcome Cardiology Surgery Laser Therapy Stem cell Cardiology and Cardiovascular Medicine business |
| Zdroj: | The heart surgery forum. 7(5) |
| ISSN: | 1522-6662 |
| Popis: | We report 2 cases in which patients with coronary heart disease not amenable for conventional revascularization underwent transmyocardial laser revascularization (TMLR) and implantation of AC133+ bone-marrow stem cells. The reason for using TMLR in combination with stem cell application is to take advantage of the synergistic angiogenic effect. The local inflammatory reaction induced by TMLR should serve as an informational platform for stem cells and may trigger their angiogenic differentiation. Functional analysis of myocardial performance after treatment in these 2 cases revealed dramatic improvement of the wall motion at the site of the TMLR and stem cell application. Because TMLR does not enhance myocardial contractility and there was no angiographic evidence of major collaterals to the ischemic region in either patient, we assume that the synergistic effect of stem cells and TMLR-induced angiogenesis occurred; however, our assumption is of a speculative nature. We think that TMLR in combination with stem cell transplantation might become a novel revascularization therapy for ischemic myocardium. |
| Databáze: | OpenAIRE |
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