Thermogenic adipocytes promote HDL turnover and reverse cholesterol transport
| Autor: | Jimmy F.P. Berbée, M. Lisa Cherradi, Alexander Bartelt, Klaus Toedter, Mariëtte R. Boon, Joerg Heeren, Markus Heine, Sander L. J. Wijers, Clara John, Nicola Schaltenberg, Christian Schlein, F. Rinninger, Wouter D. van Marken Lichtenbelt, Markus Fischer, Anna Worthmann, Julia Piepenburg, Ludger Scheja, Patrick C.N. Rensen, Stefan K. Nilsson, Andreas Niemeier |
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| Přispěvatelé: | RS: NUTRIM - R1 - Obesity, diabetes and cardiovascular health, RS: NUTRIM - HB/BW section B, RS: NUTRIM - R1 - Metabolic Syndrome |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
CD36 Antigens Male General Physics and Astronomy 030204 cardiovascular system & hematology chemistry.chemical_compound 0302 clinical medicine High-density lipoprotein Brown adipose tissue Adipocytes Multidisciplinary BROWN ADIPOSE-TISSUE Reverse cholesterol transport ADAPTIVE THERMOGENESIS Thermogenesis Läkemedelskemi Cold Temperature medicine.anatomical_structure Cholesterol Liver CARDIOVASCULAR-DISEASE Metabolome lipids (amino acids peptides and proteins) Lipoproteins HDL SCAVENGER RECEPTOR medicine.medical_specialty animal structures Cardiotonic Agents COLD-EXPOSURE Science Lipolysis TYPE-2 DIABETES-MELLITUS Hyperlipidemias Biology General Biochemistry Genetics and Molecular Biology Article 03 medical and health sciences Internal medicine medicine Animals Humans Scavenger receptor CELLULAR CHOLESTEROL Triglycerides APOLIPOPROTEIN-A-I Cholesterol HDL ENERGY-EXPENDITURE Biological Transport General Chemistry Beige Adipocytes Mice Inbred C57BL Lipoprotein Lipase 030104 developmental biology Endocrinology chemistry Medicinal Chemistry HIGH-DENSITY-LIPOPROTEIN |
| Zdroj: | Nature Communications Nature Communications, 8 Nature Communications, 8:15010. Nature Publishing Group Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017) |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/ncomms15010 |
| Popis: | Brown and beige adipocytes combust nutrients for thermogenesis and through their metabolic activity decrease pro-atherogenic remnant lipoproteins in hyperlipidemic mice. However, whether the activation of thermogenic adipocytes affects the metabolism and anti-atherogenic properties of high-density lipoproteins (HDL) is unknown. Here, we report a reduction in atherosclerosis in response to pharmacological stimulation of thermogenesis linked to increased HDL levels in APOE*3-Leiden.CETP mice. Both cold-induced and pharmacological thermogenic activation enhances HDL remodelling, which is associated with specific lipidomic changes in mouse and human HDL. Furthermore, thermogenic stimulation promotes HDL-cholesterol clearance and increases macrophage-to-faeces reverse cholesterol transport in mice. Mechanistically, we show that intravascular lipolysis by adipocyte lipoprotein lipase and hepatic uptake of HDL by scavenger receptor B-I are the driving forces of HDL-cholesterol disposal in liver. Our findings corroborate the notion that high metabolic activity of thermogenic adipocytes confers atheroprotective properties via increased systemic cholesterol flux through the HDL compartment. Activation of brown adipose tissue (BAT) reduces the development of atherosclerosis in animal models. Here the authors show that BAT activation also increases reverse cholesterol transport and turnover of high-density lipoprotein, which likely contributes to the anti-atherosclerotic effect of BAT activation. |
| Databáze: | OpenAIRE |
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