A novel locus for dilated cardiomyopathy, diffuse myocardial fibrosis, and sudden death on chromosome 10q25-26
| Autor: | Patrick T. Ellinor, Jordan T. Shin, Bernhard Pilz, Arnd Heuser, Gregor Krings, Beate Michely, Sabine Sasse-Klaassen, Brenda Gerull, G. William Dec, Bruce Coplin, Bong Seok Song, Ludwig Thierfelder, Andrea Toeppel, Hans Christian Hennies, Danita M. Yoerger, Calum A. MacRae, Peter Lange, Susanne Probst |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Cardiomyopathy Dilated Genetic Markers Male medicine.medical_specialty Adolescent Genetic Linkage Cardiomyopathy Locus (genetics) Sudden death Centimorgan Genetic linkage Internal medicine medicine Humans Genetic Predisposition to Disease Child business.industry Chromosomes Human Pair 10 Haplotype Chromosome Mapping Dilated cardiomyopathy Middle Aged medicine.disease Fibrosis Pedigree Death Sudden Cardiac Phenotype Heart failure Cardiology Female Lod Score business Cardiology and Cardiovascular Medicine Cardiomyopathies |
| Zdroj: | Journal of the American College of Cardiology. 48(1) |
| ISSN: | 1558-3597 |
| Popis: | OBJECTIVES We sought to identify the genetic locus for an inherited form of dilated cardiomyopathy (DCM) that is characterized by diffuse myocardial fibrosis and sudden death. BACKGROUND Genetic studies have mapped multiple loci for DCM, which is a major cause of nonischemic heart failure; however, the genes responsible for the majority of cases have yet to be identified. METHODS Sixty-six family members were evaluated by 12-lead electrocardiogram (ECG), echocardiogram, and laboratory studies. Individuals with echocardiographically documented DCM were defined as affected. Subjects were considered unaffected if they were older than 20 years of age, had a normal ECG and echocardiogram, no personal history of heart failure, and had no affected offspring. Genotyping was performed using polymorphic markers. RESULTS Genome-wide linkage analysis identified a novel locus for this inherited phenotype on chromosome 10q25.3-q26.13. Peak two-point logarithm of the odds scores >3.0 were obtained independently with each family using the markers D10S1773 and D10S1483, respectively. Haplotype analyses defined a critical interval of 14.0 centiMorgans between D10S1237 and D10S1723, corresponding to a physical distance of 9.5 megabases. Multipoint linkage analyses confirmed this interval and generated a peak logarithm of the odds score of 8.2 indicating odds of >100,000,000:1 in favor of this interval as the location of the gene defect responsible for DCM in these families. CONCLUSIONS We have mapped a novel locus for cardiomyopathy, diffuse myocardial fibrosis, and sudden death to chromosome 10q25-q26. The identification of the causative gene in this interval will be an important step in understanding the fundamental mechanisms of heart failure and sudden death. |
| Databáze: | OpenAIRE |
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