Fast MCsquare-Based Independent Dose Verification Platform for Pencil Beam Scanning Proton Therapy
| Autor: | Wen Chien Hsi, Ji-Yeon Park, Chunbo Liu, Xiaoying Liang, Yawei Zhang, Yuntao Song, Hansheng Feng, Zuofeng Li, Meng Wei Ho |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
Cancer Research Materials science Dose calculation Monte Carlo method 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Treatment plan dose verification Proton Therapy Humans Computer Simulation Pencil-beam scanning Proton therapy Simulation RC254-282 Monte Carlo simulation Brain Neoplasms Phantoms Imaging MCsquare Radiotherapy Planning Computer-Assisted Neoplasms. Tumors. Oncology. Including cancer and carcinogens Prostatic Neoplasms Water pencil beam scanning Radiotherapy Dosage Oncology Head and Neck Neoplasms 030220 oncology & carcinogenesis Dose verification Feasibility Studies Original Article Tomography X-Ray Computed Algorithms |
| Zdroj: | Technology in Cancer Research & Treatment Technology in Cancer Research & Treatment, Vol 20 (2021) |
| ISSN: | 1533-0338 1533-0346 |
| Popis: | Purpose: To commission MCsquare (a multi-cores CPU-based dose calculation engine) for pencil beam scanning (PBS) proton therapy, integrate it into RayStation treatment plan system (TPS) to create a dedicated platform for fast independent dose verification. Method: A MCsquare-based independent dose verification platform (MC2InRS) was developed to realize automatic dose re-calculation for clinical use, including data preparation, dose calculation, 2D/3D gamma analysis. MCsquare was commissioned based on in-air lateral dose profiles, integrated depth dose, and the absolute dose of different beam energies for Proteus®ONE. MC2InRS was validated with measurement data using various targets and depths in a water phantom. This study also investigated 15 clinical cases to demonstrate the feasibility and effectiveness of MC2InRS platform in clinic practice. Results: Between simulation and measurement, the distal range differences at 80% (R80) and 20% (R20) dose levels for each energy were below 0.05 mm, and 0.1 mm, respectively, and the absolute dose differences were below 0.5%. 29 out of 36 QA planes reached a 100% gamma passing rate (GPR) for 2%/2mm criteria, and a minimum of 98.3% gamma was obtained in water phantom between simulation and measurement. For the 15 clinical cases investigated, the average 2D GPR (2%/2mm) was 95.4%, 99.3% for MCsquare vs. measurement, MCsquare vs. TPS, respectively. The average 3D GPR (2%/2mm) was 98.9%, 95.3% for MCsquare vs. TPS in water, and computed tomography (CT), respectively. Conclusion: MC2InRS, a fast, independent dose verification platform, has been developed to perform dose verification with high accuracy and efficiency for Pencil Bream Scanning (PBS). Its potential to be applied in routine clinical practice has also been discussed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|