Occupational Exposure to Vinyl Chloride, Acrylonitrile and Styrene and Lung Cancer Risk (Europe)
| Autor: | Eleono´ra Fabiánová, Lenka Foretova, Andrea 't Mannetje, Ghislaine Scelo, Vladimir Janout, Paul Brennan, Irma Csiki, David Zaridze, Jolanta Lissowska, Tony Fletcher, Alena Slamova, Vali Constantinescu, Joelle Fevotte, Paolo Boffetta, Peter Rudnai, Adrian Cassidy, Neonila Szeszenia-Dabrowska |
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| Přispěvatelé: | Scélo, G., Constantinescu, V., Csiki, I., Zaridze, D., Szeszenia-Dabrowska, N., Rudnai, P., Lissowska, J., Fabiánová, E., Cassidy, A., Slamova, A., Foretova, L., Janout, V., Fevotte, J., Fletcher, T., Mannetje, A., Brennan, P., Boffetta, P. |
| Rok vydání: | 2004 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Lung Neoplasms Vinyl Chloride Cumulative Exposure Vinyl chloride Toxicology chemistry.chemical_compound Risk Factors Occupational Exposure Internal medicine Epidemiology Odds Ratio medicine Humans Lung cancer Styrene Aged Acrylonitrile business.industry Incidence Smoking Case-control study Odds ratio Middle Aged medicine.disease Europe Oncology chemistry Case-Control Studies Carcinogens Female business Cohort study |
| Zdroj: | Cancer Causes & Control. 15:445-452 |
| ISSN: | 0957-5243 |
| Popis: | Several industry-based cohort studies have addressed the risk of lung cancer following exposure to vinyl chloride, acrylonitrile and styrene, with inconsistent results and usually without smoking adjustment. These exposures are addressed here in a large case-control study with full adjustment for smoking. Almost 6000 subjects were included in a case-control study conducted in seven European countries. For each job they held, local experts assessed the exposure to a number of occupational agents, including vinyl chloride, acrylonitrile and styrene, on the basis of detailed occupational questionnaires. Information on tobacco consumption and other risk factors was also collected. The odds ratio (OR) for ever exposure to vinyl chloride was 1.05 (95% confidence interval, CI: 0.68-1.62) and a modest, non-significant increase in the risk of lung cancer was found in the highest exposed subgroup. The OR for ever exposure to acrylonitrile was 2.20 (95% CI: 1.11-4.36) with a positive dose-response relationship between estimated cumulative exposure and lung cancer risk. No association between exposure to styrene and lung cancer risk was found. In conclusion, we cannot exclude a weak association between occupational exposure to vinyl chloride and lung cancer risk. Exposure to acrylonitrile was associated in our study with risk of lung cancer. Exposure to styrene does not seem to increase lung cancer risk. |
| Databáze: | OpenAIRE |
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