Overexpression of TPX2 is associated with progression and prognosis of prostate cancer
Autor: | De‑Xiong Chen, Jun Zou, Weide Zhong, Zhao‑Dong Han, Rui‑Yan Huang, Fu‑Neng Jiang, Yuxiang Liang, Cong Wang |
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Jazyk: | angličtina |
Rok vydání: | 2018 |
Předmět: |
0301 basic medicine
Cancer Research prostate cancer diagnosis urologic and male genital diseases prostate cancer prognosis Metastasis 03 medical and health sciences Prostate cancer 0302 clinical medicine Medicine Oncogene business.industry Microarray analysis techniques targeting protein for Xenopus kinesin-like protein 2 Cancer Articles Cell cycle medicine.disease prostate cancer Molecular medicine 030104 developmental biology Oncology Docetaxel 030220 oncology & carcinogenesis Cancer research business medicine.drug |
Zdroj: | Oncology Letters |
ISSN: | 1792-1082 1792-1074 |
Popis: | Targeting protein for Xenopus kinesin-like protein 2 (TPX2) activates Aurora kinase A during mitosis and targets its activity to the mitotic spindle, serving an important role in mitosis. It has been associated with different types of cancer and is considered to promote tumor growth. The aim of the present study was to explore the role of TPX2 in diagnosing prostate cancer (PCa). It was identified that TPX2 expression in PCa tissues was increased compared with benign prostate tissues. Microarray analysis demonstrated that TPX2 was positively associated with the Gleason score, tumor-node-metastasis (TNM) stage, clinicopathological stage, metastasis, overall survival and biochemical relapse-free survival. In vitro studies revealed that the high expression of TPX2 in PCa cells improved proliferative, invasive and migratory abilities, and repressed apoptosis of the PCa cells, without affecting tolerance to docetaxel. The results suggested that TPX2 serves as a tumorigenesis-promoting gene in PCa, and a potential therapeutic target for patients with PCa. |
Databáze: | OpenAIRE |
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