Association of UCP1 polymorphisms with type 2 diabetes mellitus and their interaction with physical activity and sedentary behavior
| Autor: | Haisheng Yang, Xingning Mao, Qiuyu Fan, Lianguang Xie, Haiying Zhang, Xiaolang Chen, Lulin Chen, Lulu Zhang, Yingnan Lv, Chunting Dong, Tianzhu Long, Rongqing Yang |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty China endocrine system diseases Genotype Physical activity Type 2 diabetes Biology Logistic regression 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine Genetics medicine Odds Ratio Humans Exercise Alleles Triglycerides Uncoupling Protein 1 Aged Polymorphism Genetic Triglyceride Cholesterol HDL nutritional and metabolic diseases Type 2 Diabetes Mellitus General Medicine Odds ratio Sedentary behavior Middle Aged medicine.disease Lipid Metabolism 030104 developmental biology Endocrinology chemistry Diabetes Mellitus Type 2 030220 oncology & carcinogenesis Case-Control Studies Female Insulin Resistance Sedentary Behavior |
| Zdroj: | Gene. 739 |
| ISSN: | 1879-0038 |
| Popis: | Uncoupling protein 1 (UCP1) has been reported to be associated with type 2 diabetes mellitus (T2DM) in different populations, however, little is reported in Chinese population. The present study aimed to explore the association between some polymorphisms of UCP1 with T2DM and the interactions between UCP1 and physical activity/sedentary behavior (PA/SB) lifestyle in Chinese population.Three polymorphisms (rs1472268, rs3811790 and rs3811791) were genotyped in 929 T2DM patients and 1044 nondiabetic controls. The data of PA and SB were acquired. Logistic regression and linear regression were conducted to assess the association of UCP1 and T2DM and related traits.The CC genotype of rs3811791 was significantly associated with an increased risk of T2DM [odds ratio (OR) = 1.42, P = 0.042] and a higher level of triglyceride (TG) (β = 0.048, P = 0.034). This association still existed in the group of SB ≥ 3 h/d (OR = 1.66, P = 0.009) and the group of PA ≥ 150 min/week and SB ≥ 3 h/d (OR = 1.60, P = 0.034). In the group of PA 150 min/week and SB 3h/d, CC genotype was associated with a higher level of homeostatic model assessment of insulin resistance (HOMA-IR) index, and in the group of PA 150 min/week and SB ≥ 3 h/d, CC genotype was associated with increased level of TG and decreased high-density lipoprotein cholesterol (HDL-C).This study suggests that rs3811791 of UCP1 may be associated with T2DM and TG. Moreover, we demonstrate that SB interacted with rs3811791 of UCP1 was associated with T2DM, and PA interacted with rs3811791 of UCP1 was associated with the level of HOMA-IR, HDL-C, and TG. |
| Databáze: | OpenAIRE |
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