No evidence for an association of plasma homocysteine levels and refractive error – Results from the population-based Gutenberg Health Study (GHS)
Autor: | Andreas Schulz, Philipp S. Wild, Stefan Nickels, Maria Blettner, Thomas Münzel, Henk J. Blom, Lutz Joachimsen, Karl J. Lackner, Manfred E. Beutel, Wolf A. Lagrèze, Norbert Pfeiffer |
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Přispěvatelé: | Clinical Genetics |
Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
Male
Refractive error Homocysteine genetic structures Vision Visual Acuity Social Sciences Cornea chemistry.chemical_compound 0302 clinical medicine Mathematical and Statistical Techniques Risk Factors Germany Medicine and Health Sciences Myopia Medicine Psychology Public and Occupational Health Prospective Studies Prospective cohort study Generalized estimating equation Visual Impairments Multidisciplinary Eye Lens Statistics Middle Aged Refractive Errors Socioeconomic Aspects of Health Physical Sciences Regression Analysis Sensory Perception Female Anatomy Cohort study Research Article Adult Hyperhomocysteinemia medicine.medical_specialty Science Ocular Anatomy Surgical and Invasive Medical Procedures Linear Regression Analysis Research and Analysis Methods 03 medical and health sciences Ocular System Ophthalmology Linear regression Humans Risk factor Statistical Methods Aged business.industry Biology and Life Sciences medicine.disease eye diseases Health Care chemistry 030221 ophthalmology & optometry Eyes sense organs business Head 030217 neurology & neurosurgery Mathematics Neuroscience |
Zdroj: | PLoS ONE PLoS One (print), 15(4):e0231011. Public Library of Science PLoS ONE, Vol 15, Iss 4, p e0231011 (2020) |
ISSN: | 1932-6203 |
Popis: | Purpose There is a strong association between severe hyperhomocysteinemia and myopia. Thus we studied the hypothesis that even moderately increased levels of homocysteine (Hcy) might be a potentially treatable risk factor for myopia. Methods The Gutenberg Health Study (GHS) is a population-based, prospective, observational cohort study in Germany, including 15,010 participants aged between 35 and 74 at recruitment. The baseline examination was conducted from 2007–2012. Refraction was measured using autorefraction (HARK 599, Carl Zeiss AG, Jena, Germany). Hcy was measured by an immunoassay. We included only phakic participants without a history of corneal surgery or corneal laser treatment. We used linear regression models to evaluate the potential association between Hcy and refraction at baseline, and between Hcy and change in refraction between baseline and 5-year-follow-up examination. We used generalized estimating equation models to account for the correlation between fellow eyes. Results We included 13,749 participants, categorized as having no myopia (spherical equivalent > -0.75 D, 65.2%), low myopia (-0.75 D–-2.75 D, 21.5%), moderate myopia (-3.00 D– 5.75 D, 9.8%) and high myopia (≤ -6 D, 3.5%). Median Hcy levels were similar in all groups (μmol/l). We observed no association of Hcy with refraction or 5-year change in refraction in the models adjusted for age, sex and socioeconomic status. Conclusion We found no evidence for an association of Hcy levels and refractive error. |
Databáze: | OpenAIRE |
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