No evidence for an association of plasma homocysteine levels and refractive error – Results from the population-based Gutenberg Health Study (GHS)

Autor: Andreas Schulz, Philipp S. Wild, Stefan Nickels, Maria Blettner, Thomas Münzel, Henk J. Blom, Lutz Joachimsen, Karl J. Lackner, Manfred E. Beutel, Wolf A. Lagrèze, Norbert Pfeiffer
Přispěvatelé: Clinical Genetics
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Male
Refractive error
Homocysteine
genetic structures
Vision
Visual Acuity
Social Sciences
Cornea
chemistry.chemical_compound
0302 clinical medicine
Mathematical and Statistical Techniques
Risk Factors
Germany
Medicine and Health Sciences
Myopia
Medicine
Psychology
Public and Occupational Health
Prospective Studies
Prospective cohort study
Generalized estimating equation
Visual Impairments
Multidisciplinary
Eye Lens
Statistics
Middle Aged
Refractive Errors
Socioeconomic Aspects of Health
Physical Sciences
Regression Analysis
Sensory Perception
Female
Anatomy
Cohort study
Research Article
Adult
Hyperhomocysteinemia
medicine.medical_specialty
Science
Ocular Anatomy
Surgical and Invasive Medical Procedures
Linear Regression Analysis
Research and Analysis Methods
03 medical and health sciences
Ocular System
Ophthalmology
Linear regression
Humans
Risk factor
Statistical Methods
Aged
business.industry
Biology and Life Sciences
medicine.disease
eye diseases
Health Care
chemistry
030221 ophthalmology & optometry
Eyes
sense organs
business
Head
030217 neurology & neurosurgery
Mathematics
Neuroscience
Zdroj: PLoS ONE
PLoS One (print), 15(4):e0231011. Public Library of Science
PLoS ONE, Vol 15, Iss 4, p e0231011 (2020)
ISSN: 1932-6203
Popis: Purpose There is a strong association between severe hyperhomocysteinemia and myopia. Thus we studied the hypothesis that even moderately increased levels of homocysteine (Hcy) might be a potentially treatable risk factor for myopia. Methods The Gutenberg Health Study (GHS) is a population-based, prospective, observational cohort study in Germany, including 15,010 participants aged between 35 and 74 at recruitment. The baseline examination was conducted from 2007–2012. Refraction was measured using autorefraction (HARK 599, Carl Zeiss AG, Jena, Germany). Hcy was measured by an immunoassay. We included only phakic participants without a history of corneal surgery or corneal laser treatment. We used linear regression models to evaluate the potential association between Hcy and refraction at baseline, and between Hcy and change in refraction between baseline and 5-year-follow-up examination. We used generalized estimating equation models to account for the correlation between fellow eyes. Results We included 13,749 participants, categorized as having no myopia (spherical equivalent > -0.75 D, 65.2%), low myopia (-0.75 D–-2.75 D, 21.5%), moderate myopia (-3.00 D– 5.75 D, 9.8%) and high myopia (≤ -6 D, 3.5%). Median Hcy levels were similar in all groups (μmol/l). We observed no association of Hcy with refraction or 5-year change in refraction in the models adjusted for age, sex and socioeconomic status. Conclusion We found no evidence for an association of Hcy levels and refractive error.
Databáze: OpenAIRE
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