More than 10% weight loss in head and neck cancer patients during radiotherapy is independently associated with deterioration in quality of life
| Autor: | Johannes A. Langendijk, C. René Leemans, Jacqueline A.E. Langius, Patricia Doornaert, Irma M. Verdonck-de Leeuw, Anne M van Dijk, Hinke M. Kruizenga, Peter J.M. Weijs |
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| Přispěvatelé: | Nutrition and Health, Clinical Psychology, EMGO+ - Lifestyle, Overweight and Diabetes, Internal medicine, Radiation Oncology, Otolaryngology / Head & Neck Surgery, CCA - Quality of life, EMGO - Lifestyle, overweight and diabetes |
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty medicine.medical_treatment Medicine (miscellaneous) Social Environment Enteral Nutrition Quality of life SDG 3 - Good Health and Well-being Weight loss Internal medicine Weight Loss Medicine Humans Prospective Studies Prospective cohort study Social functioning Aged Nutrition and Dietetics business.industry Head and neck cancer Social environment Middle Aged medicine.disease Surgery Radiation therapy Parenteral nutrition Oncology Social Class Head and Neck Neoplasms Linear Models Quality of Life Female medicine.symptom business |
| Zdroj: | Nutrition and Cancer, 65(1), 76-83. Routledge Langius, J A E, van Dijk, A M, Doornaert, P A H, Kruizenga, H M, Langendijk, J A, Leemans, C R, Weijs, P J M & de Leeuw, I M 2013, ' More than 10% weight loss in head and neck cancer patients during radiotherapy is independently associated with deterioration in quality of life ', Nutrition and Cancer, vol. 65, no. 1, pp. 76-83 . https://doi.org/10.1080/01635581.2013.741749 |
| ISSN: | 0163-5581 |
| DOI: | 10.1080/01635581.2013.741749 |
| Popis: | The authors prospectively assessed the independent association between weight loss and deterioration in quality of life (QOL) in patients treated by radiotherapy for head and neck cancer. In 533 head and neck cancer patients treated by curative radiotherapy, changes in weight and QOL were assessed between baseline (before radiotherapy) and follow-up (12 wk after the start of radiotherapy). Patients were categorized into 4 weight loss categories: 0%, 0.1%-5.0%, 5.1%-10.0%, and >10% weight loss. The association between weight loss and change in QOL was analyzed by linear regression analysis, adjusted for sociodemographic and tumor-related characteristics, and additionally for disease specific symptoms and tube feeding. Thirty percent of patients lost 0.1%-5.0% weight, 26% lost 5.1%-10.0% weight, and 24% lost >10% weight. Adjusted regression analyses showed a significant association between weight loss and deterioration of global QOL, physical functioning, social functioning, social eating, and social contact. After additional adjustment for disease-specific symptoms and tube feeding, weight loss (>10%) remained significantly associated with global QOL, social eating, and social contact (P < 0.05). More than 10% weight loss during and directly after radiotherapy has a significant impact on social eating, social contact, and QOL in head and neck cancer patients. Copyright © 2013, Taylor & Francis Group, LLC. |
| Databáze: | OpenAIRE |
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