Cerebral and behavioral signs of impaired cognitive flexibility and stability in schizophrenia spectrum disorders
| Autor: | Ima Trempler, Udo Dannlowski, Isabel Standke, Rebekka Lencer, Ricarda Ines Schubotz |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
RT
reaction time Hippocampus BACS Brief Assessment of Cognition in Schizophrenia (Keefe et al. 2004) Gating CPZ chlorpromazine equivalents (Andreasen et al. 2010) Lateral prefrontal cortex Cognition Striatal gating Pr discrimination index medicine.diagnostic_test Dri drifts Cognitive flexibility CR correct rejections of drifts Regular Article SANS Scale for the Assessment of Negative Symptoms (Andreasen 1984b) Magnetic Resonance Imaging Distractor shielding Frontal Lobe medicine.anatomical_structure Neurology Br response bias psychological phenomena and processes SAPS Scale for the Assessment of Positive Symptoms (Andreasen 1984a) Cognitive Neuroscience Computer applications to medicine. Medical informatics R858-859.7 Prefrontal Cortex behavioral disciplines and activities FA false alarms at drifts BDI-II Becks Depression Inventory-II (Beck et al. 1996) medicine Humans Radiology Nuclear Medicine and imaging RC346-429 Anterior cingulate cortex Swi switches Neural correlates of consciousness business.industry Medial prefrontal cortex H hits at switches Prediction error processing NSS Heidelberg Scale for Neurological Soft Signs (Schröder et al. 1991) nervous system Rule switching BIS Baratt Impulsiveness Scale (Patton et al. 1995) M misses of switches Schizophrenia Neurology (clinical) Neurology. Diseases of the nervous system business Functional magnetic resonance imaging MC motor control SD standard deviation Cognition Disorders Insula Neuroscience |
| Zdroj: | NeuroImage : Clinical NeuroImage: Clinical, Vol 32, Iss, Pp 102855-(2021) |
| ISSN: | 2213-1582 |
| Popis: | Highlights • Patients are impaired regarding both, cognitive flexibility and stability. • Deficient prediction error discrimination is related to reduced striatal activation. • Decreased ACC and hippocampus activation predicts impaired rule switch detection. • Decreased frontal and insular activation predicts impaired distractor shielding. Background Manifold cognitive deficits have been reported in schizophrenia spectrum disorders, including disturbances in flexible updating to altered circumstances as well as stabilization deficits in the face of distractors. In this functional magnetic resonance imaging study, we examined the neural correlates of these deficits as two complementary components of predictive processing. Methods In 22 patients with schizophrenia spectrum disorders and 22 healthy matched control participants, we applied a serial predictive switch-drift task to assess flexibility as successful detection of prediction-rule switches, and stability as successfully ignoring distractors (“drifts”). Results Patients compared with controls less reliably detected rule switches and also less efficiently inhibited drifts. A reduced striatal response to switches or drifts correlated with weaker switch-drift-discrimination in patients, suggesting impaired gating of prediction errors. The increase in activity in anterior cingulate cortex and hippocampus for detected vs. undetected switches was reduced in patients compared to controls, which may reflect impaired behavioral adaptation following prediction errors. The comparison between shielding against distractions and undetected switches showed increased activity in the inferior frontal cortex and posterior insula in controls but not in patients. Conclusion Our results suggest new insights into the specific disruption of predictive flexibility and stability in schizophrenia spectrum disorders, which is characterized by impaired striatal gating and inadequate cortical encoding of predictive errors. |
| Databáze: | OpenAIRE |
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