The Role of the Renal Dopaminergic System and Oxidative Stress in the Pathogenesis of Hypertension
| Autor: | Waleed N. Qaddumi, Pedro A. Jose |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty kidney hypertension Medicine (miscellaneous) Review 030204 cardiovascular system & hematology medicine.disease_cause General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Dopamine Internal medicine medicine dopamine receptor oxidative stress Receptor lcsh:QH301-705.5 Kidney business.industry Dopaminergic blood pressure medicine.disease 030104 developmental biology Blood pressure medicine.anatomical_structure Endocrinology dopaminergic system lcsh:Biology (General) Dopamine receptor Pathophysiology of hypertension dopamine business Oxidative stress medicine.drug |
| Zdroj: | Biomedicines Biomedicines, Vol 9, Iss 139, p 139 (2021) |
| ISSN: | 2227-9059 |
| Popis: | The kidney is critical in the long-term regulation of blood pressure. Oxidative stress is one of the many factors that is accountable for the development of hypertension. The five dopamine receptor subtypes (D1R–D5R) have important roles in the regulation of blood pressure through several mechanisms, such as inhibition of oxidative stress. Dopamine receptors, including those expressed in the kidney, reduce oxidative stress by inhibiting the expression or action of receptors that increase oxidative stress. In addition, dopamine receptors stimulate the expression or action of receptors that decrease oxidative stress. This article examines the importance and relationship between the renal dopaminergic system and oxidative stress in the regulation of renal sodium handling and blood pressure. It discusses the current information on renal dopamine receptor-mediated antioxidative network, which includes the production of reactive oxygen species and abnormalities of renal dopamine receptors. Recognizing the mechanisms by which renal dopamine receptors regulate oxidative stress and their degree of influence on the pathogenesis of hypertension would further advance the understanding of the pathophysiology of hypertension. |
| Databáze: | OpenAIRE |
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