Immunological activities are modulated by enteral administration of an elemental diet in mice
| Autor: | Mariléia Chaves Andrade, Ana Maria Caetano Faria, J. S. Menezes, Beatriz Senra, Nelson M. Vaz, Virlânia Silva Rodrigues |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
medicine.medical_specialty
Elemental diet Ratón Lymphoid Tissue medicine.medical_treatment Enzyme-Linked Immunosorbent Assay Weaning Critical Care and Intensive Care Medicine Enteral administration Mice Enteral Nutrition Internal medicine Intestine Small Medicine Animals Secretion Lymphocytes Intestinal Mucosa Food Formulated Lamina propria Nutrition and Dietetics business.industry Flow Cytometry Immunohistochemistry Immunoglobulin A Mice Inbred C57BL medicine.anatomical_structure Cytokine Endocrinology Parenteral nutrition Immunoglobulin G Immunology business Spleen |
| Zdroj: | Clinical nutrition (Edinburgh, Scotland). 25(4) |
| ISSN: | 0261-5614 |
| Popis: | Summary Background & Aims Elemental diets (EDs) have been used successfully in treatment of some intestinal inflammatory diseases; however, the mechanism that mediates their effects is still unclear. In this study we evaluated the immunological effect of enteral administration of an ED in mice. Methods C57BL/6 mice were fed an ED (El-Diet) from weaning up to adulthood and immunological parameters were analyzed. Results El-Diet-fed mice presented an underdeveloped gut-associated-lymphoid tissue with lower numbers of TCRαβ+IELs and lamina propria cells and low levels of secretory IgA when compared to chow-fed mice. They showed a systemic decrease in the production of IgG and IgA as well as a skewing towards a Th2 profile of cytokine production upon in vitro stimulation with an increase in IL-4 and a reduction in IFN-γ and IL-6 secretion. Conclusion Our study demonstrated the role of EDs in modulating immunological activities in mice and proposes a rational for their successful use in treatment of some intestinal inflammatory diseases. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect