Alginate Gel Reinforcement with Chitin Nanowhiskers Modulates Rheological Properties and Drug Release Profile
| Autor: | Daria N. Poshina, Yury A. Skorik, Dmitry P. Romanov, Valentina A. Petrova, Sergei V. Raik, Vladimir Yu Elokhovskiy |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Alginates
Diffusion lcsh:QR1-502 Biocompatible Materials 02 engineering and technology 010402 general chemistry chitin 01 natural sciences Biochemistry Article lcsh:Microbiology chemistry.chemical_compound Tissue engineering Chitin Rheology Molecular Biology Alginic acid tetracycline alginic acid Viscosity Hydrogels 021001 nanoscience & nanotechnology Polyelectrolyte 0104 chemical sciences Drug Liberation chemistry Chemical engineering Drug delivery Self-healing hydrogels drug delivery hydrogel 0210 nano-technology |
| Zdroj: | Biomolecules, Vol 9, Iss 7, p 291 (2019) Biomolecules Volume 9 Issue 7 |
| Popis: | Hydrogels are promising materials for various applications, including drug delivery, tissue engineering, and wastewater treatment. In this work, we designed an alginate (ALG) hydrogel containing partially deacetylated chitin nanowhiskers (CNW) as a filler. Gelation in the system occurred by both the protonation of alginic acid and the formation of a polyelectrolyte complex with deacetylated CNW surface chains. Morphological changes in the gel manifested as a honeycomb structure in the freeze-dried gel, unlike the layered structure of an ALG gel. Disturbance of the structural orientation of the gels by the introduction of CNW was also expressed as a decrease in the intensity of X-ray diffraction reflexes. All studied systems were non-Newtonian liquids that violated the Cox-Merz rule. An increase in the content of CNW in the ALG-CNW hydrogel resulted in increases in the yield stress, maximum Newtonian viscosity, and relaxation time. Inclusion of CNW prolonged the release of tetracycline due to changes in diffusion. The first phases (0&ndash 5 h) of the release profiles were well described by the Higuchi model. ALG-CNW hydrogels may be of interest as soft gels for controlled topical or intestinal drug delivery. |
| Databáze: | OpenAIRE |
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