Computed Tomographic Perfusion Imaging for the Prediction of Response and Survival to Transarterial Chemoembolization of Hepatocellular Carcinoma
| Autor: | Manca Garbajs, Klara Kregar, Ana Leban, Rok Dezman, Peter Popovič, Matjaz Bunc |
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| Rok vydání: | 2017 |
| Předmět: |
business.industry
R895-920 drug-eluting beads transarterial chemoembolization Perfusion scanning hepatocellular carcinoma medicine.disease computed tomography perfusion imaging Response to treatment survival digestive system diseases 030218 nuclear medicine & medical imaging Computed tomographic Medical physics. Medical radiology. Nuclear medicine 03 medical and health sciences 0302 clinical medicine Oncology 030220 oncology & carcinogenesis Hepatocellular carcinoma medicine Computed Tomography Perfusion Imaging Radiology Nuclear Medicine and imaging response to treatment Nuclear medicine business Research Article |
| Zdroj: | Radiology and Oncology Radiology and oncology (Ljubljana) Radiology and Oncology, Vol 52, Iss 1, Pp 14-22 (2017) |
| ISSN: | 1318-2099 |
| Popis: | Background The purpose of this retrospective cohort study was to evaluate the clinical value of computed tomographic perfusion imaging (CTPI) parameters in predicting the response to treatment and overall survival in patients with hepatocellular carcinoma (HCC) treated with drug-eluting beads transarterial chemoembolization (DEBTACE). Patients and methods Between December 2010 and January 2013 eighteen patients (17 men, 1 woman; mean age 69 ± 5.8 years) with intermediate stage HCC underwent CTPI of the liver prior to treatment with DEBTACE. Treatment response was evaluated on follow-up imaging according to modified Response Evaluation Criteria in Solid Tumors. Pre-treatment CTPI parameters were compared between patients with complete response and partial response with a Student t-test. We compared survival times with Kaplan-Meier method. Results CTPI parameters of patients with complete response and others did not show statistical significant difference. The mean survival time was 25.4 ± 3.2 months (95%; CI: 18.7-32.1). Survival was statistically significantly longer in patients with hepatic blood flow (BF) lower than 50.44 ml/100 ml/min (p = 0.033), hepatic blood volume (BV) lower than 13.32 ml/100 ml (p = 0.028) and time to peak (TTP) longer than 19.035 s (p = 0.015). Conclusions CTPI enables prediction of survival in patients with intermediate stage HCC, treated with DEBTACE based on the pre-treatment values of BF, BV and TTP perfusion parameters. CT perfusion imaging can’t be used to predict treatment response to DEBTACE. |
| Databáze: | OpenAIRE |
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