Claustral structural connectivity and cognitive impairment in drug naïve Parkinson’s disease
| Autor: | Giuseppe Anastasi, Enricomaria Mormina, Alessandro Calamuneri, Angelo Quartarone, Viviana Lo Buono, Alessandro Arrigo, Giuseppina Rizzo, Francesco Corallo, Michele Gaeta, Alberto Cacciola, Gaetana Chillemi, Giuseppe Di Lorenzo, Silvia Marino, Demetrio Milardi |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
Parkinson's disease Cognitive Neuroscience Claustrum Grey matter 050105 experimental psychology Diffusion MRI 03 medical and health sciences Cellular and Molecular Neuroscience Behavioral Neuroscience 0302 clinical medicine Cognition Cognitive assessment Nuclear Medicine and Imaging medicine Humans 0501 psychology and cognitive sciences Radiology Nuclear Medicine and imaging Cognitive Dysfunction Cognitive decline Gray Matter Aged Connectivity business.industry 05 social sciences Neuropsychology Brain Parkinson Disease Middle Aged medicine.disease Drug-naïve medicine.anatomical_structure Diffusion Magnetic Resonance Imaging Neurology Psychiatry and Mental Health Parkinson’s disease Female Claustrum Cognitive assessment Tractography Connectivity Diffusion MRI Parkinson’s disease Radiology Nuclear Medicine and Imaging Neurology Cognitive Neuroscience Neurology (clinical) Cellular and Molecular Neuroscience Psychiatry and Mental Health Behavioral Neuroscience Neurology (clinical) Nerve Net business Radiology Neuroscience Tractography 030217 neurology & neurosurgery medicine.drug |
| Popis: | The claustrum is a thin grey matter structure which is involved in a wide brain network. Previous studies suggested a link between claustrum and Parkinson’s Disease (PD), showing how α-synuclein pathology may affect claustral neurons as well as how α-synuclein immunoreactivity may correlate with the onset of cognitive dysfunctions. Our aim is to investigate, via diffusion MRI, claustral structural network changes in drug naive PD patients, with the goal to understand whether such changes may contribute to cognitive decline in PD. 15 drug naive PD patients and 15 age-matched controls were enrolled; MR protocol was performed on a 3T scanner. Whole brain probabilistic tractography was obtained using Constrained Spherical Deconvolution (CSD) diffusion model. Connectivity matrices were estimated based on a robust anatomical parcellation of structural T1w images. In PD group, impaired subnetworks were correlated with psychological examinations. We found decreased claustral connectivity in PD patients compared to controls, especially with areas mainly involved in visuomotor and attentional systems. Moreover, we found a positive correlation between MoCA and density of pathways connecting ipsilaterally claustrum to left (r = 0.578, p = 0.021) and right (r = 0.640, p = 0.020) Pars Orbitalis. Our results support the hypothesis of claustral involvement in cognitive decline in drug naive PD patients. |
| Databáze: | OpenAIRE |
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