Association among extracellular superoxide dismutase genotype, plasma concentration, and comorbidity in the very old and centenarians
| Autor: | Nobuyoshi Hirose, Yasumichi Arai, Hideyuki Okano, Michiyo Takayama, Tetsuo Adachi, Takashi Sasaki, Yukiko Abe |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Genotype SOD3 Science Renal function Comorbidity Article 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Risk Factors Internal medicine Diabetes mellitus medicine Extracellular Humans Clinical genetics Aged 80 and over Creatinine Multidisciplinary Adiponectin business.industry Superoxide Dismutase Age Factors Odds ratio medicine.disease 030104 developmental biology Endocrinology chemistry Diabetes Mellitus Type 2 Medicine Female business 030217 neurology & neurosurgery Biomarkers Glomerular Filtration Rate |
| Zdroj: | Scientific Reports Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021) |
| ISSN: | 2045-2322 |
| Popis: | Superoxide dismutase 3 (SOD3), an antioxidant enzyme, is known as extracellular SOD (EC-SOD) because it is the predominant form in extracellular fluids. The diversity of plasma EC-SOD concentration is associated with the SOD3 p.R231G missense variant genotype. To clarify the association among SOD3 genotype, plasma EC-SOD concentration, and comorbidity in Oldest Old, we analyzed genome-wide associations with plasma EC-SOD concentration and associations between EC-SOD concentration and medical history classified by the SOD3 genotype in the Very Old (85–99 years old, n = 505) and Centenarians (over 100 years old, n = 595). The results revealed that SOD3 p.R231G was the most significant variant associated with plasma EC-SOD concentration. Although no significant difference was observed in medical histories between the SOD3 p.R231G variant non-carriers and carriers, higher EC-SOD concentration in plasma of SOD3 p.R231G variant non-carriers was associated with a high odds ratio for chronic kidney disease (OR = 2.70, 95% CI = 1.98–3.72) and low odds ratio for diabetes mellitus (DM) (OR = 0.61, 95% CI = 0.39–0.95). Comparison with 11 plasma biomarkers for age-related disease showed that plasma EC-SOD concentration correlated with adiponectin and estimated glomerular filtration rate with creatinine correction; therefore, we deduced that EC-SOD co-operates with adiponectin and possesses beneficial functions for DM in the Oldest Old. |
| Databáze: | OpenAIRE |
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