4-Aminopyridine and dendrotoxin induce repetitive firing in rat visceral sensory neurones by blocking a slowly inactivating outward current
| Autor: | C. E. Stansfeld, J.V. Halliwell, Stephen J. Marsh, D.A. Brown |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Potassium
Neurotoxins Dendrotoxin chemistry.chemical_element Neural Inhibition Action Potentials Aminopyridines Sensory system Ion Channels medicine Reaction Time Animals Neurons Afferent Elapid Venoms Chemistry General Neuroscience 4-Aminopyridine Nodose Ganglion Vagus Nerve Sensory neuron Rats medicine.anatomical_structure Convulsant Biophysics Ganglia Neuroscience medicine.drug |
| Zdroj: | Neuroscience letters. 64(3) |
| ISSN: | 0304-3940 |
| Popis: | In a subpopulation of rat visceral afferent neurones we have identified a potassium (K) current which is novel to mammalian neurones. It activates rapidly at potentials positive to - 70 mV but shows only slow and incomplete inactivation and is inhibited by 1-30 microM 4-aminopyridine (4-AP) or 3-10 nM dendrotoxin (DTX). Inhibition of this slowly inactivating current suppresses spike adaptation and leads to pronounced repetitive firing. In contrast, other visceral afferent neurones possessing the normal transient A-current were insensitive to 4-AP at concentrations below 100 microM. We suggest that inhibition of the slowly inactivating current may contribute to the convulsant actions of 4-AP and DTX. |
| Databáze: | OpenAIRE |
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