The roles of lipid and glucose metabolism in modulation of β-amyloid, tau, and neurodegeneration in the pathogenesis of Alzheimer disease
| Autor: | Naoyuki eSato, Ryuichi eMorishita |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Apolipoprotein E
Aging medicine.medical_specialty Cognitive Neuroscience Protein metabolism Review Carbohydrate metabolism Biology Bioinformatics lcsh:RC321-571 Pathogenesis chemistry.chemical_compound Internal medicine medicine tau abeta lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Aβ diabetes Cholesterol Neurodegeneration neurodegeneration cholesterol Lipid metabolism medicine.disease Endocrinology chemistry lipids (amino acids peptides and proteins) Alzheimer's disease Neuroscience |
| Zdroj: | Frontiers in Aging Neuroscience, Vol 7 (2015) Frontiers in Aging Neuroscience |
| ISSN: | 1663-4365 |
| DOI: | 10.3389/fnagi.2015.00199 |
| Popis: | Diabetes is a risk factor for Alzheimer disease (AD). Apolipoprotein E (ApoE) and several genes related to AD have recently been identified by genome-wide association studies (GWAS) as being closely linked to lipid metabolism. Lipid metabolism and glucose-energy metabolism are closely related. Here, we review the emerging evidence regarding the roles of lipid and glucose metabolism in the modulation of β-amyloid, tau, and neurodegeneration during the pathogenesis of AD. Disruption of homeostasis of lipid and glucose metabolism affects production and clearance of β-amyloid and tau phosphorylation, and induces neurodegeneration. A more integrated understanding of the interactions among lipid, glucose, and protein metabolism is required to elucidate the pathogenesis of AD and to develop next-generation therapeutic options. |
| Databáze: | OpenAIRE |
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