Treatments for infantile Hemangioma: A systematic review and network meta-analysis
| Autor: | Qiang Fei, Yu Lin, Xian Chen |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Cochrane Library
01 natural sciences law.invention 0302 clinical medicine Randomized controlled trial law Prednisone Medicine 030212 general & internal medicine Network meta-analysis SUCRA surface under the cumulative ranking curve PRO propranolol PED prednisone lcsh:R5-920 IH infantile hemangioma PDL pulsed dye laser OR odds ratios General Medicine IMQ imiquimod L a longer treatment duration Meta-analysis S a shorter treatment duration ATL atenolol Nd Nd:YAG laser Hemangioma lcsh:Medicine (General) CAP captopril Research Paper medicine.drug LPDL PDL at a long pulse duration medicine.medical_specialty Therapeutics Propranolol Laser PDL and Nd:YAG laser 03 medical and health sciences Internal medicine 0101 mathematics Adverse effect H a higher dose TA triamcinolone business.industry 010102 general mathematics Atenolol medicine.disease β topical β-blockers treatment CI confidence intervals RCT randomized clinical trials NMA network meta-analysis business |
| Zdroj: | EClinicalMedicine, Vol 26, Iss, Pp 100506-(2020) EClinicalMedicine |
| ISSN: | 2589-5370 |
| DOI: | 10.1016/j.eclinm.2020.100506 |
| Popis: | Background Infantile hemangioma (IH) is common in children, which may bring about cosmetically disfiguring, functional impairment, and exhibiting complications. There had been various therapies and we aimed to assess the efficacy and adverse effects of different therapies through network meta-analysis. Methods We searched PubMed, Embase, Cochrane Library and Web of Science (from database inception to April 11, 2020) for studies assessing the efficacy, success rate and adverse effects. Direct pairwise comparison and a network meta-analysis under random effects were performed. We also assessed the ranking probability. Findings A total of 30 randomized clinical trials with more than 20 different therapeutic regimens were identified. Treatment combined propranolol orally with laser could improve the curative effect than monotherapy. Laser with topical β blockers showed more efficiency than others whether in children under 6 months or not. The long-pulsed dye laser might be the best laser therapy. A higher dose and a longer treatment duration of propranolol orally achieved a higher success rate and increased side effects. Plus pulse dye laser with propranolol had the lowest incidence of adverse reactions, such as ulcer, color sink and color reduction. Interpretation A combination of β blockers and laser might be the first-line treatment of IHs and a longer pulsed dye laser is preferred. Funding No funding was received. |
| Databáze: | OpenAIRE |
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