Correlations between Iron Metabolism Parameters, Inflammatory Markers and Lipid Profile Indicators in Patients with Type 1 and Type 2 Diabetes Mellitus
| Autor: | Tatiana V. Saprina, N. N. Musina, A. P. Zima, Tatiana S Prokhorenko, Alexander Kanev |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Medicine (miscellaneous) lcsh:Medicine 030209 endocrinology & metabolism Type 2 diabetes 030204 cardiovascular system & hematology Article C-reactive protein 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine anemia of chronic disease Internal medicine Diabetes mellitus Hyperlipidemia medicine hyperlipidemia Type 1 diabetes iron deficiency anemia medicine.diagnostic_test business.industry lcsh:R Type 2 Diabetes Mellitus medicine.disease Endocrinology chemistry inflammation diabetes mellitus Microalbuminuria Glycated hemoglobin erythrocyte sedimentation rate tumor necrosis factor-α Lipid profile business |
| Zdroj: | Journal of Personalized Medicine Volume 10 Issue 3 Journal of Personalized Medicine, Vol 10, Iss 70, p 70 (2020) |
| ISSN: | 2075-4426 |
| Popis: | This study aims to establish relationships between inflammatory status, ferrokinetics and lipid metabolism in patients with diabetes mellitus. Subclinical inflammation was assessed by levels of high-sensitive C-reactive protein, tumor necrosis factor-&alpha and erythrocyte sedimentation rate. Iron metabolism parameters included complete blood count, serum iron, transferrin and ferritin. Metabolic status assessment included lipid profile, glycated hemoglobin and microalbuminuria measurement. As a result of the study it was possible to establish both general (universal) and diabetes mellitus (DM) type-dependent relationships between the parameters of lipid profile and metabolic control in DM. High-density lipoprotein cholesterol (HDL-C) levels negatively correlated with microalbuminuria (r = &minus 0.293 p ˂ 0.05 for type 1 diabetes and r = &minus 0.272 p ˂ 0.05 for type 2 diabetes). Ferritin concentration positively correlated with triglyceride level (r = 0.346 p ˂ 0.05 for type 1 diabetes and r = 0.244 p ˂ 0.05 for type 2 diabetes). In type 1 diabetes, a negative correlation was discovered between estimated glomerular filtration rate (eGFR) and LDL-C (r = &minus 0.480 p ˂ 0.05), very low-density-lipoprotein cholesterol (VLDL-C) (r = &minus 0.490 p ˂ 0.05) and triglycerides (r = &minus 0.553 p ˂ 0.05), and a positive one between C-reactive protein concentration and triglyceride level (r = 0.567 p ˂ 0.05). Discovered relationships between lipid profile indices, inflammatory status and microalbuminuria confirmed mutual influence of hyperlipidemia, inflammation and nephropathy in diabetes patients. Obtained results justify the strategy of early hypolipidemic therapy in patients with diabetes mellitus to prevent the development and progression of microvascular complications. |
| Databáze: | OpenAIRE |
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