Central herpes virus infection: Altered toxicity to d-amphetamine sulfate
| Autor: | Edward Sikora, John Hotchin, Richard F. Seegal |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Male
Dextroamphetamine Time Factors Inoculation Herpes Simplex Mice Inbred Strains Endogeny General Medicine Biology medicine.disease_cause General Biochemistry Genetics and Molecular Biology Mice D-amphetamine sulfate Herpes simplex virus Herpes virus Immunology Toxicity medicine Animals Encephalitis General Pharmacology Toxicology and Pharmaceutics |
| Zdroj: | Life Sciences. 29:777-782 |
| ISSN: | 0024-3205 |
| DOI: | 10.1016/0024-3205(81)90032-1 |
| Popis: | We have examined the effects of peritoneal injections of d-amphetamine sulfate (d-amp) on mortality in mice inoculated peripherally and then intracerebrally (IC) infected with herpes simplex virus type 1 (HSV). On day 5 post-IC infection, the mice were significantly less sensitive to the lethal effects of d-amp than were control mice. No differences in mortality were noted after exposure to d-amp 14 days after IC infection. Animals that had received HSV-IC only were significantly more sensitive to the lethal effects of d-amp than control animals. We conclude that: (a) the effect is temporary in nature; (b) the protective mechanism can be overcome by particularly high levels of d-amp; (c) the protective effect may involve alterations in endogenous levels of central catecholamines. The peripherally and then centrally infected mouse not only provides a means of examining long-term interactions between infectious agents and drugs, but may also provide a model for examining virus-induced neurological disorders of brain catecholamines. |
| Databáze: | OpenAIRE |
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