| Autor: |
Alan Huang, Robert Schlegel, Andrew X. Zhu, Dalila Sellami, Benjamin H. Lee, Yan Wang, Michael R. Palmer, Marissa N. Balak, Adnan Derti, Manway Liu, David Ruddy, David Yang, Panisa Pochanard, Khee Chee Soo, Richard Ong, David Chen, Stephen L. Chan, Huai-Xiang Hao, Hung Huynh |
| Rok vydání: |
2023 |
| DOI: |
10.1158/1535-7163.22501846 |
| Popis: |
TSC2 loss in HCC cell lines leads to mTOR activation. (A) Reverse Phase Protein Array (RPPA) analysis of nine HCC cell lines for TSC2 protein levels and phosphorylation levels of S6K1, 4E-BP1, S6 and AKT. (B) Immunoblot of TSC2 wild-type HuH-7 cells treated with inhibitors of PI3K, AKT or MEK. (C) p-S6K1(T389) immunoblot of TSC2-null HCC cell lines treated with varying concentrations of everolimus. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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