An X-Chromosome Scan Reveals a Locus for Fat Distribution in Chromosome Region Xp21–22
| Autor: | R. Arlen Price, Robin L. Kilker, Weidong Li |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Leptin
Male medicine.medical_specialty X Chromosome Genotype Genetic Linkage Endocrinology Diabetes and Metabolism Black People Adipose tissue Locus (genetics) Biology Quantitative trait locus Body fat percentage Body Mass Index Internal medicine Chromosome regions Internal Medicine medicine Humans Obesity Finland X chromosome Genetics Chromosome Mapping medicine.disease United States Europe Phenotype Endocrinology Adipose Tissue Body Composition Body Constitution Female France |
| Zdroj: | Diabetes. 51:1989-1991 |
| ISSN: | 1939-327X 0012-1797 |
| DOI: | 10.2337/diabetes.51.6.1989 |
| Popis: | Several groups have completed autosomal genome scans for human obesity, but only two have examined the X chromosome. A French group reported linkage of BMI to Xp and Xq markers, and a Finnish group reported linkage of BMI to Xq. We scanned the X chromosome in two cohorts, 190 European-American families (940 members) and 43 African-American families (208 members). We examined five correlated obesity phenotypes, BMI, body fat percentage, hip and waist circumferences, and plasma leptin concentration. We also examined leptin resistance (leptin/BMI) and fat patterning (waist-to-hip ratio [WHR]). Variables were adjusted for age within generation, race, and sex. We genotyped 20 markers with average spacing of 10 cM and no interval >22 cM and conducted nonparametric analyses. Suggestive linkage was found for WHR only. Linkage was supported in both family sets, and support was especially strong for females. Z scores for analyses of female phenotypes were 2.69, 1.73, and 2.37 (P = 0.0036, 0.0418, and 0.0089) for African-Americans, European-Americans, and the combined sample, respectively. The peaks were 51–73 cM from the p terminus, 14–34 cM distal of the French report in Xp22. Our results suggest that a quantitative trait locus influencing fat distribution in women may lie in chromosome region Xp21–22; however, the linked interval is large and differs substantially from that of the French and Finnish groups. Given the positive but divergent results, it would be worthwhile for others to examine the X chromosome. |
| Databáze: | OpenAIRE |
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