Aerobic interval exercise improves parameters of nonalcoholic fatty liver disease (NAFLD) and other alterations of metabolic syndrome in obese Zucker rats
| Autor: | Rosario Martínez, Marie Goua, Garyfallia Kapravelou, María López-Jurado, Milagros Galisteo, Eduardo Fernández-Segura, Jesús M. Porres, A. Andrade, Francisco Arrebola, Pilar Aranda, Elena Nebot, Virginia A. Aparicio, Daniel Camiletti-Moirón, Giovanna Bermano |
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| Rok vydání: | 2015 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Time Factors Physiology Endocrinology Diabetes and Metabolism Type 2 diabetes AMP-Activated Protein Kinases Antioxidants Interval training AMP-activated protein kinase Non-alcoholic Fatty Liver Disease Physiology (medical) Internal medicine Nonalcoholic fatty liver disease medicine Animals Genetic Predisposition to Disease Phosphorylation Metabolic Syndrome Nutrition and Dietetics biology Area under the curve VO2 max Lipid metabolism General Medicine medicine.disease Lipids Exercise Therapy Rats Zucker Enzyme Activation PPAR gamma Disease Models Animal Phenotype Endocrinology Liver biology.protein Metabolic syndrome Biomarkers Signal Transduction |
| Zdroj: | Applied Physiology, Nutrition, and Metabolism. 40:1242-1252 |
| ISSN: | 1715-5320 1715-5312 |
| Popis: | Metabolic syndrome (MS) is a group of metabolic alterations that increase the susceptibility to cardiovascular disease and type 2 diabetes. Nonalcoholic fatty liver disease has been described as the liver manifestation of MS. We aimed to test the beneficial effects of an aerobic interval training (AIT) protocol on different biochemical, microscopic, and functional liver alterations related to the MS in the experimental model of obese Zucker rat. Two groups of lean and obese animals (6 weeks old) followed a protocol of AIT (4 min at 65%–80% of maximal oxygen uptake, followed by 3 min at 50%–65% of maximal oxygen uptake for 45–60 min, 5 days/week, 8 weeks of experimental period), whereas 2 control groups remained sedentary. Obese rats had higher food intake and body weight (P < 0.0001) and suffered significant alterations in plasma lipid profile, area under the curve after oral glucose overload (P < 0.0001), liver histology and functionality, and antioxidant status. The AIT protocol reduced the severity of alterations related to glucose and lipid metabolism and increased the liver protein expression of PPARγ, as well as the gene expression of glutathione peroxidase 4 (P < 0.001). The training protocol also showed significant effects on the activity of hepatic antioxidant enzymes, although this action was greatly influenced by rat phenotype. The present data suggest that AIT protocol is a feasible strategy to improve some of the plasma and liver alterations featured by the MS. |
| Databáze: | OpenAIRE |
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