A Patient with Non-alcoholic Steatohepatitis Complicated by Multiple Myeloma
| Autor: | Momoko Akashi, Toshiro Sugiyama, Kazuto Tajiri, Koichi Tsuneyama, Akinori Wada, Terumi Takahara, Satoshi Yasumura, Masami Minemura, Kengo Kawai |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Liver Cirrhosis
0301 basic medicine medicine.medical_specialty osteopontin Case Report Gastroenterology Proinflammatory cytokine 03 medical and health sciences hedgehog pathway 0302 clinical medicine Asian People stomatognathic system Non-alcoholic Fatty Liver Disease Internal medicine Ascites Internal Medicine Humans Medicine Hedgehog Proteins Osteopontin Multiple myeloma Aged biology medicine.diagnostic_test business.industry General Medicine Jaundice medicine.disease Hedgehog signaling pathway multiple myeloma 030104 developmental biology Liver biopsy biology.protein Female 030211 gastroenterology & hepatology non-alcoholic steatohepatitis Steatohepatitis medicine.symptom business |
| Zdroj: | Internal Medicine |
| ISSN: | 1349-7235 0918-2918 |
| DOI: | 10.2169/internalmedicine.0092-17 |
| Popis: | A 68-year-old woman with liver dysfunction was diagnosed with nonalcoholic steatohepatitis (NASH) stage 1. Three years later, she showed massive ascites and jaundice. A trans-jugular liver biopsy confirmed advanced cirrhosis, suggesting that her liver fibrosis had progressed rapidly. At the same time, she was diagnosed with multiple myeloma (MM). In this case, the plasma levels of osteopontin (OPN), a proinflammatory cytokine that promotes liver fibrosis progression through the hedgehog pathway and is increased in patients with MM, were increased. This increased OPN expression was accompanied by the upregulation of the hedgehog pathway in this patient, suggesting that the MM-associated increase in OPN had promoted the progression of liver fibrosis through the hedgehog pathway. The progression of liver fibrosis should be monitored in patients with NASH if other diseases, such as MM, are present. |
| Databáze: | OpenAIRE |
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