The ability of certain antimutagenic agents to prevent development of antibiotic resistance
| Autor: | Delbert M. Shankel, Segaran P. Pillai, Lester A. Mitscher, Christine A. Pillai |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
DNA
Bacterial Drug Staphylococcus aureus medicine.drug_class Health Toxicology and Mutagenesis media_common.quotation_subject medicine.medical_treatment Antibiotics Colony Count Microbial Biological Transport Active Microbial Sensitivity Tests Drug resistance In Vitro Techniques Pharmacology Biology Antioxidants Catechin Microbiology Antibiotic resistance Ethidium Escherichia coli Genetics medicine media_common Chemotherapy Dose-Response Relationship Drug Tea Antimutagenic Agents Drug Resistance Microbial Antimicrobial Green tea DNA Damage |
| Zdroj: | Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 496:61-73 |
| ISSN: | 1383-5718 |
| DOI: | 10.1016/s1383-5718(01)00219-4 |
| Popis: | Resistance to multiple antimicrobial agents has now become a prominent fact of contemporary life. It is believed that poor patient compliance, e.g. interrupted or premature cessation of therapy; and misuse or abuse of antibiotics, e.g. wrong antibiotic or insufficient dose, play important roles in resistance development. We present evidence that, this form of resistance often stems from spontaneous mutations accompanied by the positive selecting pressure of the doses of antibiotics being between the MIC and MBC levels. A number of antimutagenic agents, e.g. green tea catechins, and other antioxidants, etc. are able to suppress the emergence of resistance. In many cases, these agents are capable of exerting these effects at doses which by themselves produce no visible effect on growth. In a number of cases antimutagenic substances capable of preventing resistance emergence are present in normal food stuffs. These effects are exerted against resistance to tetracyclines, fluoroquinolones, macrolides, beta-lactams, aminoglycosides and the like. The implications of these laboratory findings for practical chemotherapy are discussed. |
| Databáze: | OpenAIRE |
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