Association of oral microbiota with lung cancer risk in a low-income population in the Southeastern USA

Autor: William J. Blot, Jirong Long, Jie Wu, Regina Courtney, Jiajun Shi, Wei Zheng, Yaohua Yang, Hua Xie, Qiuyin Cai, Xiaofei Wang, Xiao-Ou Shu
Rok vydání: 2021
Předmět:
Zdroj: Cancer Causes Control
ISSN: 1573-7225
0957-5243
Popis: PURPOSE: Oral microbiome plays an important role in oral health and systemic diseases, including cancer. We aimed to prospectively investigate the association of oral microbiome with lung cancer risk. METHODS: We analyzed 156 incident lung cancer cases (73 European Americans and 83 African Americans) and 156 individually matched controls nested within the Southern Community Cohort Study. Oral microbiota were assessed using 16S rRNA gene sequencing in pre-diagnostic mouth rinse samples. Paired t-test and the permutation multivariate analysis of variance test were used to evaluate lung cancer risk association with alpha diversity or beta diversity, respectively. Conditional logistic regression models were used to evaluate the association of individual bacterial abundance or prevalence with lung cancer risk. RESULTS: No significant differences were observed for alpha or beta diversity between lung cancer cases and controls. Abundance of families Lachnospiraceae_[XIV], Peptostreptococcaceae_[XI] and Erysipelotrichaceae, and species Parvimonas micra was associated with decreased lung cancer risk, with odds ratios (ORs) and 95% confidence intervals (CIs) of 0.76 (0.59–0.98), 0.80 (0.66–0.97), 0.81 (0.67–0.99), and 0.83 (0.71–0.98), respectively (all P
Databáze: OpenAIRE
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