Scavenging of photogenerated ROS by Oxicams. Possible biological and environmental implications
| Autor: | M. Paulina Montaña, Sandra Miskoski, Gabriela V. Ferrari, Vanesa Muñoz, Norman A. García, José Natera, Eduardo L. Gutiérrez, Walter A. Massad |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Antioxidant
Light Pyridines Riboflavin medicine.medical_treatment Thiazines Biophysics Context (language use) Oxidative phosphorylation Meloxicam Photochemistry RIBOFLAVIN Piroxicam Superoxides Tenoxicam medicine Organic chemistry Radiology Nuclear Medicine and imaging Photosensitizer Photodegradation PHOTODEGRADATION Photolysis Radiation Singlet Oxygen Radiological and Ultrasound Technology Rhodamines Chemistry Otras Ciencias Químicas Anti-Inflammatory Agents Non-Steroidal Tryptophan Ciencias Químicas PHOTOPROTECTION ROS Free Radical Scavengers Thiazoles Photoprotection OXICAMS Tyrosine PHOTOSENSITIZATION Reactive Oxygen Species Oxidation-Reduction Water Pollutants Chemical CIENCIAS NATURALES Y EXACTAS medicine.drug |
| Zdroj: | Journal of Photochemistry and Photobiology B: Biology. 153:233-239 |
| ISSN: | 1011-1344 |
| DOI: | 10.1016/j.jphotobiol.2015.09.024 |
| Popis: | The profusely employed drugs Piroxicam (Piro), Tenoxicam (Teno) and Meloxicam (Melo) belonging to the non-steroidal antiinflammatory drug (NSAID) family of the Oxicams (Oxis) were studied in the frame of two specific conditions: (a) their ROS scavenging ability, in relation to a possible biological antioxidant action and (b) their photodegradability under environmental conditions, in the context of Oxi-contaminated waters. Singlet molecular oxygen (O2(1Δg)) and superoxide radical anion (O2 -) were photogenerated through Riboflavin (Rf, vitamin B2)-photosensitization in aqueous and aqueous-methanolic solutions in the presence of Oxi concentrations in the range 50-500 μM. The visible-light absorber vitamin is currently present in all types of natural waters and constitutes the most frequent endogenous photosensitizer in mammals. Hence, it was employed in order to mimic both natural sceneries of interest. All three Oxis quench O2(1Δg) with rate constants in the order of 108 M- 1 s- 1 showing a significant photodegradation efficiency given by a dominant reactive fashion for deactivation of the oxidative species. Although this is not a desirable property in the context of photoprotection upon prolonged photoirradiation, constitutes in fact a promissory aspect for the degradation NSAIDs, in waste waters. Indirect evidence indicates that Melo is also oxidized through a O2 --mediated component. The simultaneous presence of Piro plus tryptophan or tyrosine under Rf-photosensitizing conditions, which has taken the amino acids as photooxidizable model residues in a proteinaceous environment, indicates that the NSAID induces a protection of the biomolecules against photodynamic degradation. Fil: Ferrari, Gabriela Verónica. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Química. Area de Química Física; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Natera, Jose Eduardo. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Química; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Montaña, Maria Paulina. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Área Química General e Inorgánica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Muñoz, Vanesa Alejandra. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Área Química General e Inorgánica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Gutiérrez, Eduardo Luciano. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Área Química General e Inorgánica; Argentina Fil: Massad, Walter Alfredo. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Química; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Miskoski, Sandra. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Química; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Garcia, Norman Andino. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Química; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina |
| Databáze: | OpenAIRE |
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