Omega-3 PUFA and aspirin as adjuncts to periodontal debridement in patients with periodontitis and type 2 diabetes mellitus: Randomized clinical trial
| Autor: | Nídia Cristina Castro dos Santos, Thomas E. Van Dyke, Mauro Pedrine Santamaria, Cássia Fernandes Araújo, Naira Maria Rebelatto Bechara Andere, Alpdogan Kantarci, Andrea Carvalho De Marco |
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| Přispěvatelé: | Universidade Estadual Paulista (Unesp), The Forsyth Institute, Guarulhos University |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Periodontal Debridement aspirin Type 2 diabetes Placebo immunomodulation Gastroenterology Article law.invention 03 medical and health sciences 0302 clinical medicine Randomized controlled trial Double-Blind Method law Internal medicine Diabetes mellitus Periodontal Attachment Loss medicine Clinical endpoint Humans Periodontal Pocket periodontitis Periodontitis Aspirin diabetes omega-3 fatty acids business.industry 030206 dentistry medicine.disease 030104 developmental biology Diabetes Mellitus Type 2 inflammation Chronic Periodontitis Periodontics business medicine.drug |
| Zdroj: | Scopus Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP J Periodontol |
| Popis: | Made available in DSpace on 2020-12-12T01:29:27Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-01-01 Background: Supplementation with omega-3 polyunsaturated fatty acids (ω-3 PUFA) and low-dose aspirin (ASA) have been proposed as a host modulation regimen to control chronic inflammatory diseases. The aim of this study was to investigate the clinical and immunological impact of orally administered ω-3 PUFA and ASA as adjuncts to periodontal debridement for the treatment of periodontitis in patients type 2 diabetes. Methods: Seventy-five patients (n = 25/group) were randomly assigned to receive placebo and periodontal debridement (CG), ω-3 PUFA + ASA (3 g of fish oil/d + 100 mg ASA/d for 2 months) after periodontal debridement (test group [TG]1), or ω-3 PUFA + ASA (3 g of fish oil/d + 100 mg ASA/d for 2 months) before periodontal debridement (TG2). Periodontal parameters and GCF were collected at baseline (t0), 3 months after periodontal debridement and ω-3 PUFA + ASA or placebo for TG1 and CG (t1), after ω-3 PUFA + ASA (before periodontal debridement) for TG2 (t1), and 6 months after periodontal debridement (all groups) (t2). GCF was analyzed for cytokine levels by multiplex ELISA. Results: Ten patients (40%) in TG1 and nine patients (36%) in TG2 achieved the clinical endpoint for treatment (less than or equal to four sites with probing depth ≥ 5 mm), as opposed to four (16%) in CG. There was clinical attachment gain in moderate and deep pockets for TG1. IFN-γ and interleukin (IL)-8 levels decreased over time for both test groups. IL-6 levels were lower for TG1. HbA1c levels reduced for TG1. Conclusion: Adjunctive ω-3 and ASA after periodontal debridement provides clinical and immunological benefits to the treatment of periodontitis in patients with type 2 diabetes. Division of Periodontics Unesp – São Paulo State University Institute of Science and Technology Center for Clinical and Translational Research The Forsyth Institute Dental Research Division Guarulhos University Division of Periodontics Unesp – São Paulo State University Institute of Science and Technology |
| Databáze: | OpenAIRE |
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