Case Report: Identification of SARS-CoV-2 in Cerebrospinal Fluid by Ultrahigh-Depth Sequencing in a Patient With Coronavirus Disease 2019 and Neurological Dysfunction
| Autor: | Tian Qin, Xiao-Ping Chen, Haofeng Xiong, Yao Sun, Jianbo Tan, Xinmin Xu, Huizhu Wang, Xin Lu, Jin Fangfang, Pan Xiang, Ruihong Li, Fei Zhao, Biao Kan, Hebing Guo, Yufeng Liu, Lili Gao, Jingyuan Liu, Lin Pu, Han Zheng, Hongyu Ren, Xuexin Hou, Chuansheng Li, Yanwen Xiong, Jingjing Hao, Ming Zhang, Haijian Zhou, Zhenpeng Li, Jie Gong, Jing Yang, Yajie Wang |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Nervous system
Pathology medicine.medical_specialty Coronavirus disease 2019 (COVID-19) viruses Central nervous system Case Report Genome Cerebrospinal fluid Medicine skin and connective tissue diseases Pathogen Intracranial pressure Whole genome sequencing lcsh:R5-920 business.industry SARS-CoV-2 fungi virus diseases COVID-19 General Medicine central nervous system infection metagenomic next-generation sequencing body regions medicine.anatomical_structure business lcsh:Medicine (General) |
| Zdroj: | Frontiers in Medicine Frontiers in Medicine, Vol 8 (2021) |
| ISSN: | 2296-858X |
| Popis: | We reported that the complete genome sequence of SARS-Coronavirus-2 (SARS-CoV-2) was obtained from a cerebrospinal fluid (CSF) sample by ultrahigh-depth sequencing. Fourteen days after onset, seizures, maxillofacial convulsions, intractable hiccups and a significant increase in intracranial pressure developed in an adult coronavirus disease 2019 patient. The complete genome sequence of SARS-CoV-2 obtained from the cerebrospinal fluid indicates that SARS-CoV-2 can invade the central nervous system. In future, along with nervous system assessment, the pathogen genome detection and other indicators are needed for studying possible nervous system infection of SARS-CoV-2. |
| Databáze: | OpenAIRE |
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