Molecular predictive markers in tumors of the gastrointestinal tract
| Autor: | George Nasioulas, Angeliki Tsirigoti, Nikolaos Tsoulos, Eugenia Bourkoula, Angela Apessos, Georgia Pepe, Eirini Papadopoulou, Konstantinos Agiannitopoulos, Georgios N. Tsaousis, Chrisoula Efstathiadou, Vasiliki Metaxa-Mariatou |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_treatment Review Bioinformatics Targeted therapy 03 medical and health sciences Predictive biomarkers Gastrointestinal tract Somatic mutations Next generation sequencing medicine Gastrointestinal cancer Liquid biopsy Predictive biomarker business.industry Gastroenterology medicine.disease Molecular biomarkers Advanced cancer 030104 developmental biology Oncology Molecular Profile business |
| Zdroj: | World Journal of Gastrointestinal Oncology |
| ISSN: | 1948-5204 |
| Popis: | Gastrointestinal malignancies are among the leading causes of cancer-related deaths worldwide. Like all human malignancies they are characterized by accumulation of mutations which lead to inactivation of tumor suppressor genes or activation of oncogenes. Advances in Molecular Biology techniques have allowed for more accurate analysis of tumors' genetic profiling using new breakthrough technologies such as next generation sequencing (NGS), leading to the development of targeted therapeutical approaches based upon biomarker-selection. During the last 10 years tremendous advances in the development of targeted therapies for patients with advanced cancer have been made, thus various targeted agents, associated with predictive biomarkers, have been developed or are in development for the treatment of patients with gastrointestinal cancer patients. This review summarizes the advances in the field of molecular biomarkers in tumors of the gastrointestinal tract, with focus on the available NGS platforms that enable comprehensive tumor molecular profile analysis. |
| Databáze: | OpenAIRE |
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