Synergy of cell-cell repulsion and vacuolation in a computational model of lumen formation
| Autor: | Sonja E. M. Boas, Roeland M. H. Merks |
|---|---|
| Přispěvatelé: | Evolutionary Intelligence |
| Rok vydání: | 2014 |
| Předmět: |
Pathology
medicine.medical_specialty Angiogenesis computational modelling Biomedical Engineering Biophysics Neovascularization Physiologic Bioengineering Vacuole Biology cell-cell repulsion Biochemistry Models Biological Exocytosis Biomaterials angiogenesis vacuolation Cell Movement Extracellular medicine cellular Potts model Computer Simulation Research Articles Cellular Potts model medicine.anatomical_structure cell–cell repulsion Vacuoles Intracellular lumen formation Biotechnology Lumen (unit) Blood vessel |
| Zdroj: | Journal of the Royal Society Interface |
| ISSN: | 1742-5662 1742-5689 |
| Popis: | A key step in blood vessel development (angiogenesis) is lumen formation: the hollowing of vessels for blood perfusion. Two alternative lumen formation mechanisms are suggested to function in different types of blood vessels. Thevacuolationmechanism is suggested for lumen formation in small vessels by coalescence of intracellular vacuoles, a view that was extended to extracellular lumen formation by exocytosis of vacuoles. Thecell–cell repulsionmechanism is suggested to initiate extracellular lumen formation in large vessels by active repulsion of adjacent cells, and active cell shape changes extend the lumen. We used an agent-based computer model, based on the cellular Potts model, to compare and study both mechanisms separately and combined. An extensive sensitivity analysis shows that each of the mechanisms on its own can produce lumens in a narrow region of parameter space. However, combining both mechanisms makes lumen formation much more robust to the values of the parameters, suggesting that the mechanisms may work synergistically and operate in parallel, rather than in different vessel types. |
| Databáze: | OpenAIRE |
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