Matrix Gla protein is associated with coronary artery calcification as assessed by electron-beam computed tomography
| Autor: | Akane Kizu, Cees Vermeer, Atsushi Shioi, Hiromichi Taniwaki, Shuichi Jono, Paul Dissel, Yoshiki Nishizawa, Yuji Ikari, Shigeru Saito, Kotaro Hasegawa |
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| Předmět: |
Male
Pathology medicine.medical_specialty Coronary Artery Disease Severity of Illness Index Coronary artery disease Risk Factors Diabetes mellitus Matrix gla protein Hyperlipidemia medicine Humans cardiovascular diseases Myocardial infarction Aged Extracellular Matrix Proteins biology business.industry Calcium-Binding Proteins nutritional and metabolic diseases Calcinosis Hematology Middle Aged medicine.disease Thrombosis Coronary Vessels Arterial calcification cardiovascular system biology.protein Female business Tomography X-Ray Computed Calcification |
| Zdroj: | Scopus-Elsevier |
| Popis: | SummaryMatrix Gla protein (MGP) is an extracellular matrix protein with wide tissue distribution. It has been demonstrated that the expression of MGP is detected not only in the normal blood vessels but also calcified atherosclerotic plaques, and that MGP deficient mice develop extensive arterial calcification. MGP is thought to be a regulator of vascular calcification. A recent clinical study demonstrates the association between polymorphisms of the MGP gene and increased risk of myocardial infarction. However, there are no reports of the relationship between serum MGP levels and coronary artery calcification (CAC). We evaluated the severity of CAC using electron-beam computed tomography (EBCT), and measured serum MGP levels by enzyme-linked immunosorbent assay in 115 subjects with suspected coronary artery disease. CAC scores were correlated with traditional risk factors, such as age, gender, hypertension, diabetes, hyperlipidemia and smoking. The serum MGP levels were lower in patients with CAC than in those without CAC (p400) coronary calcification, respectively. We found that serum MGP levels are inversely correlated with the severity of CAC. These data suggest a possible role for MGP in the development of vascular calcification. |
| Databáze: | OpenAIRE |
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